Neutrophil-lymphocyte ratio as a predictive factor for tumor staging in colorectal cancer
| Autor: | Gülay Özgehan, Hülagü Kargıcı, Tevfik Küçükpınar, Hakan Güzel, Hasan Bostanci, Köksal Bilgen, Şahin Kahramanca, Ismail Kaya |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Colorectal cancer Neutrophils Lymphocyte Tumor Staging Metastasis Leukocyte Count Young Adult Predictive Value of Tests Internal medicine Tumor stage medicine Humans Key words: Systemic inflammatory response syndrome colorectal neoplasms neoplasm staging In patient Lymphocytes Aged Neoplasm Staging Aged 80 and over business.industry fungi General Medicine Middle Aged medicine.disease Predictive factor medicine.anatomical_structure Abdomen Female business Colorectal Neoplasms |
| Zdroj: | Volume: 44, Issue: 3 365-368 Turkish Journal of Medical Sciences |
| ISSN: | 1300-0144 1303-6165 |
| Popis: | In the preoperative period, simple methods to identify the tumor stage of colorectal cancer patients are needed. In recent years, the neutrophil-lymphocyte ratio (NLR) has been used as a predictive parameter for systemic inflammatory response in many different clinical entities. This study aims to determine if the NLR predicts the tumor stage in colorectal cancer patients in the preoperative period. Materials and methods: A total of 206 patients diagnosed with colorectal cancer and admitted for surgical treatment over a 6-year period were identified from a retrospectively maintained database. NLR was calculated from preoperative full blood counts. NLRs were compared with the tumor stages as determined in histopathological reports and scanning tests to determine the extent of metastasis. Results: We found NLRs to be statistically higher in patients with T3 and T4 tumors than in patients with T1 and T2 tumors (mean: 5.261 vs. 4.499, respectively, P = 0.010). Similarly, we found statistically higher NLR values in the N1 and N2 groups than in the N0 group (mean: 6.597 vs. 4.501, respectively, P < 0.001). Additionally, NLRs were statistically higher in M1 patients than in M0 patients (mean: 8.261 vs. 5.158, respectively, P = 0.004). Conclusion: In the preoperative period, NLR was found to be a valuable predictive parameter for tumor staging in patients with colorectal cancer, thus informing us as to the kind of tumor we will meet when we open the abdomen. |
| Databáze: | OpenAIRE |
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