Novel poly(butylene succinate) nanocomposites containing strontium hydroxyapatite nanorods with enhanced osteoconductivity for tissue engineering applications
| Autor: | Ourania-Menti Goudouri, Dimitrios N. Bikiaris, Aldo R. Boccaccini, Maria Filippousi, G. Van Tendeloo, Maria Nerantzaki, Rainer Detsch, Zoi Terzopoulou, Alina Gruenewald |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Materials science
Nanocomposite Polymers and Plastics Biocompatibility General Chemical Engineering Organic Chemistry Poly(butylene succinate) lcsh:Chemical technology Polybutylene succinate Nanocomposites Hydrolysis Chemistry Chemical engineering Polymerization Enzymatic hydrolysis tissue engineering Scanning transmission electron microscopy Materials Chemistry lcsh:TA401-492 Nanorod lcsh:Materials of engineering and construction. Mechanics of materials lcsh:TP1-1185 Physical and Theoretical Chemistry Composite material strontium hydroxyapatite nanor |
| Zdroj: | eXPRESS Polymer Letters, Vol 9, Iss 9, Pp 773-789 (2015) Express polymer letters |
| ISSN: | 1788-618X |
| Popis: | Three series of poly(butylene succinate) (PBSu) nanocomposites containing 0.5, 1 and 2.5 wt% strontium hydroxyapatite [Sr-5(PO4)(3)OH] nanorods (SrHAp nrds) were prepared by in situ polymerisation. The structural effects of Sr-5(PO4)(3)OH nanorods, for the different concentrations, inside the polymeric matrix (PBSu), were studied through high angle annular dark field scanning transmission electron microscopy (HAADF-STEM). HAADF-STEM measurements revealed that the SrHAp nanorods at low concentrations are dispersed inside the polymeric PBSu matrix while in 1 wt% some aggregates are formed. These aggregations affect the mechanical properties giving an enhancement for the concentration of 0.5 wt% SrHAp nrds in tensile strength, while a reduction is recorded for higher loadings of the nanofiller. Studies on enzymatic hydrolysis revealed that all nanocomposites present higher hydrolysis rates than neat PBSu, indicating that nanorods accelerate the hydrolysis degradation process. In vitro bioactivity tests prove that SrHAp nrds promote the formation of hydroxyapatite on the PBSu surface. All nanocomposites were tested also in relevant cell culture using osteoblast-like cells (MG-63) to demonstrate their biocompatibility showing SrHAp nanorods support cell attachment. |
| Databáze: | OpenAIRE |
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