Influence of CYP1A1, CYP2E1, GSTM3 and NAT2 genetic polymorphisms in oral cancer susceptibility: results from a case-control study in Rio de Janeiro
| Autor: | Paul Brennan, Paolo Boffetta, Ana Hatagima, Sergio Koifman, Rosalina Jorge Koifman, Christiane de Fátima Silva Marques |
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| Přispěvatelé: | Marques, C.F.S., Koifman, S., Koifman, R.J., Boffetta, P., Brennan, P., Hatagima, A. |
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Cancer Research Adolescent Arylamine N-Acetyltransferase Mutant allele Biology Risk Assessment Cytochrome P-450 CYP1A1 Humans Genetic Predisposition to Disease Carcinogen Aged Glutathione Transferase Genetics Polymorphism Genetic Molecular epidemiology Case-control study Cancer susceptibility Heterozygote advantage Cytochrome P-450 CYP2E1 CYP2E1 Middle Aged Peripheral blood Oncology Case-Control Studies Immunology Female Mouth Neoplasms Aryl Hydrocarbon Hydroxylases Oral Surgery CYP1A1 CYP2E1 GSTM3 and NAT2 genetic polymorphisms in oral cancer Brazil |
| Zdroj: | Oral oncology. 42(6) |
| ISSN: | 1368-8375 |
| Popis: | Xenobiotic metabolizing enzymes are involved in the detoxification of many carcinogens and may be important in modulating cancer susceptibility. CYP1A1, CYP2E1, GSTM3, and NAT2 polymorphisms were determined in peripheral blood DNA of 231 oral cancer patients and 212 hospital controls in Rio de Janeiro, Brazil, using the PCR-RFLP technique. NAT2 polymorphism distribution was different between cases and controls (P = 0.035), with an overrepresentation of NAT2*11 mutant allele in controls. Risk analysis showed that NAT2 4/4 individuals (OR = 1.95, 95% CI = 1.05-3.60) and combined GSTM3 and NAT2 heterozygotes (OR = 1.94, 95% CI = 1.04-3.66) were at increased oral cancer risk. No statistically significant association was observed for CYP1A1 and CYP2E1 polymorphisms. Our results suggest that NAT2 polymorphism, alone or combined with GSTM3, may modulate susceptibility to oral cancer in Rio de Janeiro. © 2005 Elsevier Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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