Effect of prostacyclin on pulmonary vascular response to thrombin in awake sheep
| Autor: | Asrar B. Malik, S. K. Lo, M. B. Perlman |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Pulmonary Circulation
medicine.medical_specialty Platelet Aggregation Neutrophils Physiology Hypertension Pulmonary Blood Pressure Prostacyclin chemistry.chemical_compound Thrombin Physiology (medical) Internal medicine medicine Animals Platelet Sheep Chemistry Zymosan Proteins Epoprostenol medicine.anatomical_structure Endocrinology Circulatory system Immunology Vascular resistance Vascular Resistance lipids (amino acids peptides and proteins) Lymph Pulmonary Embolism circulatory and respiratory physiology medicine.drug Blood vessel |
| Zdroj: | Journal of Applied Physiology. 60:546-553 |
| ISSN: | 1522-1601 8750-7587 |
| Popis: | We determined the effects of infusion of prostacyclin (PGI2) and 6-alpha-carba-PGI2 (6-cPGI2), a stable PGI2 analogue, on pulmonary transvascular fluid and protein fluxes after intravascular coagulation induced by thrombin. Studies were made in control awake sheep prepared with lung lymph fistulas (n = 6) and in similarly prepared awake sheep pretreated with either 6-cPGI2 (n = 5) or PGI2 (n = 5). Both prostacyclin compounds (500 ng X kg-1 X min-1) were infused intravenously. All groups were challenged with 80 U/kg thrombin. Pulmonary arterial pressure (Ppa), pulmonary vascular resistance (PVR), pulmonary lymph flow (Qlym), lymph protein clearance (Qlym X lymph/plasma protein concentration ratio), and neutrophil and platelet counts were determined. In vitro tests assessed sheep neutrophil chemotaxis and chemiluminescence and platelet aggregation. In both 6-cPGI2 and PGI2 groups, the increases in Qlym after thrombin were less than those in the control group. The increase in lymph protein clearance in the 6-cPGI2 group was the same as that in control, whereas the increase in clearance in the PGI2 group was reduced. PVR and Ppa increased to a greater extent in the 6-cPGI2 group than in the control group, whereas the increases in PVR and Ppa were inhibited in the PGI2 group. Neutrophil and platelet counts decreased after thrombin in PGI2 and 6-cPGI2 groups, as they did in the control group. Neither 6-cPGI2 altered neutrophil chemotaxis induced by thrombin and chemiluminescence induced by opsonized zymosan. Both prostacyclin compounds inhibited platelet aggregation induced by ADP or thrombin.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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