Celsior Preserved Cardiac Mechanoenergetics Better Than Popular Solutions in Canine Hearts
| Autor: | Hiroyuki Suga, Takahiko Kiyooka, Gentaro Iribe, Takeshi Imaoka, Fumihiko Kajiya, Shunji Sano, Kozo Ishino, Waso Fujinaka, Yu Oshima, Juichiro Shimizu, Satoshi Mohri |
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| Rok vydání: | 2006 |
| Předmět: |
Pulmonary and Respiratory Medicine
Cardiac function curve medicine.medical_treatment Organ Preservation Solutions chemistry.chemical_element Disaccharides Oxygen Electrolytes Dogs Oxygen Consumption Glutamates Preservation solutions Animals Medicine Histidine Mannitol Viaspan Heart transplantation biology business.industry Fissipedia Significant difference Heart biology.organism_classification Glutathione Myocardial Contraction Biomechanical Phenomena chemistry Anesthesia Ventricular pressure Heart Transplantation Surgery Energy Metabolism Cardiology and Cardiovascular Medicine business |
| Zdroj: | The Annals of Thoracic Surgery. 81:658-664 |
| ISSN: | 0003-4975 |
| DOI: | 10.1016/j.athoracsur.2005.07.067 |
| Popis: | Background Better protective effects of Celsior on cardiac function than the other conventional solutions have been reported in acute experiments and in clinical trials for at-risk patients. However, no study has yet precisely elucidated how these preservation solutions affect cardiac mechanoenergetics. Therefore, we evaluated the effects of St. Thomas' Hospital solution No. 2, University of Wisconsin solution, and Celsior on left ventricular contractility (E max : end-systolic pressure–volume ratio) and oxygen consumption. Methods We used 32 canine excised cross-circulated hearts. Twenty-three hearts served as donor hearts after hypothermic ischemia with one of the three solutions, and the remaining 9 served as controls. After arrest with each solution, the hearts were preserved for 4 hours at 4°C. Then, we measured left ventricular pressure, volume, and oxygen consumption to obtain E max and the relation between ventricular pressure–volume area (a measure of total mechanical energy) and oxygen consumption. We also evaluated the oxygen cost of E max by changing E max with calcium administration. Results Celsior did not significantly affect E max (6.3 ± 2.4 in control versus 5.3 ± 1.3 mm Hg · mL −1 · 100 g with Celsior) nor the oxygen cost of E max (1.2 ± 0.6 versus 1.6 ± 0.5 mL O 2 · mL · mm Hg −1 · beat −1 · 100 g −2 , respectively). In contrast, St. Thomas' Hospital and University of Wisconsin solutions significantly decreased E max (4.5 ± 1.1 and 3.5 ± 0.9 mm Hg · mL −1 · 100 g, respectively) and increased the oxygen cost of E max (2.5 ± 0.8 and 2.4 ± 0.9 mL O 2 · mL · mm Hg −1 · beat −1 · 100 g −2 , respectively) compared with control and Celsior-preserved hearts. The slope and intercept of the oxygen consumption versus pressure–volume area relation showed no significant difference among the four groups. Conclusions Celsior showed better protective effects on cardiac mechanoenergetics than St. Thomas' Hospital and University of Wisconsin solutions in the acute phase of heart transplantation. |
| Databáze: | OpenAIRE |
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