Exercise intervention on cardiorespiratory fitness in rheumatoid arthritis patients with high cardiovascular disease risk

Autor: M. Sobejana, J. van den Hoek, G. S. Metsios, G. D. Kitas, M. van der Leeden, S. Verberne, H. T. Jorstad, M. Pijnappels, W. F. Lems, M. T. Nurmohamed, M. van der Esch
Přispěvatelé: Rehabilitation medicine, AMS - Ageing & Vitality, AMS - Musculoskeletal Health, APH - Aging & Later Life, APH - Health Behaviors & Chronic Diseases, ACS - Heart failure & arrhythmias, Rheumatology, AII - Inflammatory diseases, AMS - Tissue Function & Regeneration, ACS - Atherosclerosis & ischemic syndromes, AMS - Rehabilitation & Development, APH - Societal Participation & Health, Neuromechanics, Cardiology, AMS - Sports
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Clinical Rheumatology, 41(12), 3725-3734. Springer London
Clinical rheumatology, 41(12), 3725-3734. Springer London
Sobejana, M, van den Hoek, J, Metsios, G S, Kitas, G D, van der Leeden, M, Verberne, S, Jorstad, H T, Pijnappels, M, Lems, W F, Nurmohamed, M T & van der Esch, M 2022, ' Exercise intervention on cardiorespiratory fitness in rheumatoid arthritis patients with high cardiovascular disease risk : a single-arm pilot study ', Clinical Rheumatology, vol. 41, no. 12, pp. 3725-3734 . https://doi.org/10.1007/s10067-022-06343-4
ISSN: 0770-3198
Popis: Objective: In patients with rheumatoid arthritis (RA) with cardiovascular disease risk, it is unknown whether exercises are safe, improve cardiorespiratory fitness and reduce disease-related symptoms and cardiovascular-disease (CVD) risk factors. We aimed to investigate in RA patients with CVD risk: (1) safety of medium to high-intensity aerobic exercises, (2) potential changes of cardiorespiratory fitness and (3) disease activity and CVD risk factors in response to the exercises. Methods: Single-arm pilot-exercise intervention study including 26 consecutive patients (21 women) with > 4% 10-year risk of CVD mortality according to the Dutch Systematic Coronary Risk Evaluation. Aerobic exercises consisted of two supervised-sessions and five home-sessions per week for 12 weeks. Patients were required to exercise at intensities between 65 and 85% of their maximum heart rate. To assess safety, we recorded exercise related adverse events. Before and after the exercises, cardiorespiratory fitness was assessed with a graded maximal oxygen-uptake exercise test, while disease activity was evaluated via the Disease Activity Score-28 (DAS28) using the erythrocyte segmentation rate (ESR). Resting blood pressure, ESR and total cholesterol were assessed as CVD risk factors. Results: Twenty out of 26 patients performed the 12-week exercises without any adverse events. According to patients, withdrawals were unrelated to the exercises. Exercises increased cardiorespiratory fitness (pre: 15.91 vs. post: 18.15 ml.kg−1 min−1, p = 0.003) and decreased DAS28 (pre: 2.86 vs. post: 2.47, p = 0.04). No changes were detected in CVD risk factors. Conclusion: A 12-week exercise intervention seems to be safe and improves cardiorespiratory fitness and disease activity in patients with RA with a high risk for cardiovascular diseases.Key Points1. Rheumatoid arthritis patients with high cardiovascular disease risk were able to perform a maximum exercise test and a 12-week aerobic-based medium-to-high intensity exercise intervention.2. The exercise intervention improved cardiorespiratory fitness and disease activity in rheumatoid arthritis patients with high cardiovascular disease risk.3. Cardiorespiratory fitness levels were still low post-exercise intervention (i.e. 18.15 ml.kg−1min−1 compared to the 20.9 ml.kg−1min−1 baseline mean of the RA patients without CVD risk).
Databáze: OpenAIRE
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