High serum serotonin in sudden infant death syndrome
| Autor: | Andrew L. Frelinger, Elisabeth A. Haas, Hoa Tran, Harry P.W. Kozakewich, Hannah C. Kinney, Khosrow Adeli, David S. Paterson, Robin L. Haynes, Alan D. Michelson, Richard D. Goldstein, Gerard T. Berry, Anja J. Gerrits, Felicia L. Trachtenberg, Emma K. Giles, Othon J. Mena |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine Serotonin Pathology medicine.medical_specialty Genotype Physiology Serotonergic Sudden death Cohort Studies Asphyxia 03 medical and health sciences 0302 clinical medicine Risk Factors Polymorphism (computer science) medicine Humans Chromatography High Pressure Liquid Serotonin transporter Serotonin Plasma Membrane Transport Proteins Polymorphism Genetic Multidisciplinary biology Infant Hydroxyindoleacetic Acid Biological Sciences Sudden infant death syndrome 030104 developmental biology Case-Control Studies biology.protein Biomarker (medicine) Female Autopsy medicine.symptom Biomarkers Sudden Infant Death 030217 neurology & neurosurgery Brain Stem |
| Zdroj: | Proceedings of the National Academy of Sciences. 114:7695-7700 |
| ISSN: | 1091-6490 0027-8424 |
| Popis: | Sudden infant death syndrome (SIDS), the leading cause of postneonatal infant mortality, likely comprises heterogeneous disorders with the common phenotype of sudden death without explanation upon postmortem investigation. Previously, we reported that ∼40% of SIDS deaths are associated with abnormalities in serotonin (5-hydroxytryptamine, 5-HT) in regions of the brainstem critical in homeostatic regulation. Here we tested the hypothesis that SIDS is associated with an alteration in serum 5-HT levels. Serum 5-HT, adjusted for postconceptional age, was significantly elevated (95%) in SIDS infants (n = 61) compared with autopsied controls (n = 15) [SIDS, 177.2 ± 15.1 (mean ± SE) ng/mL versus controls, 91.1 ± 30.6 ng/mL] (P = 0.014), as determined by ELISA. This increase was validated using high-performance liquid chromatography. Thirty-one percent (19/61) of SIDS cases had 5-HT levels greater than 2 SDs above the mean of the controls, thus defining a subset of SIDS cases with elevated 5-HT. There was no association between genotypes of the serotonin transporter promoter region polymorphism and serum 5-HT level. This study demonstrates that SIDS is associated with peripheral abnormalities in the 5-HT pathway. High serum 5-HT may serve as a potential forensic biomarker in autopsied infants with SIDS with serotonergic defects. |
| Databáze: | OpenAIRE |
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