Role of the Baroreceptor Reflexes and Vasoactive Polypeptides in the Corticotropin Release Evoked by Hypotension
| Autor: | E. S. Redgate |
|---|---|
| Rok vydání: | 1968 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Mean arterial pressure Pituitary gland Baroreceptor Hypophysectomy Corticotropin-Releasing Hormone medicine.medical_treatment Pressoreceptors Femoral artery Bradykinin Endocrinology Adrenocorticotropic Hormone Internal medicine medicine.artery medicine Animals Aorta Denervation business.industry Adrenalectomy Carotid Sinus medicine.anatomical_structure Anesthesia Cats Reflex Hypotension Secretory Rate business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Endocrinology. 82:704-720 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endo-82-4-704 |
| Popis: | The factors involved in the mediation of ACTH release in the cat in response to hypotension have been investigated. Reduction of mean arterial pressure from control levels of over 100 mm Hg to a hypotensive level of 35 mm Hg by bleeding from the femoral artery resulted in a mean increment in plasma ACTH concentration of 4.5 ± 0.82 (5) mU ACTH/100 ml. After adrenalectomy of 2 hr duration, the increment evoked by hypotension was increased to 26.7 ± 5.59 (3) mU/100 ml plasma. Hypophysectomy of 20 min duration eliminated the change in plasma ACTH concentration evoked by hypotension. Occlusion of the common carotid arteries evoked an increment in plasma ACTH concentration. Prior vagosympathectomy increased the increment induced by carotid occlusion and decreased the increment in response to hypotension. Carotid-aortic denervation resulted in a 50% decrease in the ACTH increment evoked by hypotension. The residual hypotensively elicited ACTH increment persisted after C1 cord section in carotid-aortic denervated... |
| Databáze: | OpenAIRE |
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