Attentional salience and the neural substrates of response inhibition in borderline personality disorder
| Autor: | Andy C. H. Lee, Marc Walter, C. Cane, Undine E. Lang, Johannes Wrege, Dean Carcone, Stefan Borgwardt, Anthony C. Ruocco |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.diagnostic_test
Parietal lobe Impulsivity medicine.disease behavioral disciplines and activities 030227 psychiatry 03 medical and health sciences Psychiatry and Mental health 0302 clinical medicine Salience (neuroscience) Go/no go mental disorders medicine medicine.symptom Psychology Functional magnetic resonance imaging Neuroscience Borderline personality disorder 030217 neurology & neurosurgery Applied Psychology Frontal Pole Response inhibition |
| Zdroj: | Psychological Medicine. 52:3451-3459 |
| ISSN: | 1469-8978 0033-2917 |
| DOI: | 10.1017/s0033291721000118 |
| Popis: | BackgroundImpulsivity is a central symptom of borderline personality disorder (BPD) and its neural basis may be instantiated in a frontoparietal network involved in response inhibition. However, research has yet to determine whether neural activation differences in BPD associated with response inhibition are attributed to attentional saliency, which is subserved by a partially overlapping network of brain regions.MethodsPatients with BPD (n = 45) and 29 healthy controls (HCs; n = 29) underwent functional magnetic resonance imaging while completing a novel go/no-go task with infrequent odd-ball trials to control for attentional saliency. Contrasts reflecting a combination of response inhibition and attentional saliency (no-go > go), saliency processing alone (oddball > go), and response inhibition controlling for attentional saliency (no-go > oddball) were compared between BPD and HC.ResultsCompared to HC, BPD showed less activation in the combined no-go > go contrast in the right posterior inferior and middle-frontal gyri, and less activation for oddball > go in left-hemispheric inferior frontal junction, frontal pole, superior parietal lobe, and supramarginal gyri. Crucially, BPD and HC showed no activation differences for the no-go > oddball contrast. In BPD, higher vlPFC activation for no-go > go was correlated with greater self-rated BPD symptoms, whereas lower vlPFC activation for oddball > go was associated with greater self-rated attentional impulsivity.ConclusionsPatients with BPD show frontoparietal disruptions related to the combination of response inhibition and attentional saliency or saliency alone, but no specific response inhibition neural activation difference when attentional saliency is controlled. The findings suggest a neural dysfunction in BPD underlying attention to salient or infrequent stimuli, which is supported by a negative correlation with self-rated impulsiveness. |
| Databáze: | OpenAIRE |
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