Effects of bilingualism on white matter atrophy in mild cognitive impairment: a diffusion tensor imaging study
| Autor: | Maria-Antònia Parcet, Joaquín Escudero, Vicente Belloch, Lidón Marin-Marin, César Ávila, Miguel Baquero, Víctor Costumero |
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| Rok vydání: | 2020 |
| Předmět: |
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medicine.medical_specialty Bilingualism Mildcognitive impairment Multilingualism Audiology White matter 03 medical and health sciences 0302 clinical medicine Cognitive Reserve Fractional anisotropy medicine Humans Dementia Cingulum (brain) Cognitive Dysfunction 030212 general & internal medicine Aged Cognitive reserve business.industry Fornix Brain medicine.disease bilingualism diffusion tensor imaging mild cognitive impairment White Matter Diffusiontensor imaging Diffusion Tensor Imaging Boston Naming Test medicine.anatomical_structure Neurology Anisotropy Female Neurology (clinical) Atrophy Nerve Net business 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | EUROPEAN JOURNAL OF NEUROLOGY r-FIHGUV. Repositorio Institucional de Producción Científica de la Fundación de Investigación del Hospital General de Valencia instname r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe Repositori Universitat Jaume I Universitat Jaume I |
| ISSN: | 1468-1331 1351-5101 |
| DOI: | 10.1111/ene.14135 |
| Popis: | Background and purpose Previous investigations show that bilinguals exhibit the first symptoms of dementia 4-5 years later than monolinguals. Therefore, bilingualism has been proposed as a cognitive reserve mechanism. Recent studies have advanced towards an understanding of the brain mechanisms underlying bilingualism's protection against dementia, but none of them deals with white matter (WM) diffusion. Methods In this study, the topic was investigated by measuring WM integrity in a sample of 35 bilinguals and 53 passive bilinguals with mild cognitive impairment. Results No significant differences were found between the groups in cognitive level, education, age or sex. However, bilinguals showed higher mean diffusivity in the fornix, but higher fractional anisotropy, lower mean diffusivity, axial diffusivity and radial diffusivity in the parahippocampal cingulum, and lower radial diffusivity in the right uncinate fasciculus. Significant correlations were also found between WM integrity in the left parahippocampal cingulum and the Boston Naming Test in passive bilinguals. Conclusions These results suggest that bilingualism contributes to a differential pattern of WM disintegration due to mild cognitive impairment in fibers related to bilingualism and memory. |
| Databáze: | OpenAIRE |
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