A proposed symmetry forbidden oxidation mechanism for the bacterial luciferase catalyzed reaction
| Autor: | James N. Lowe, Jonathan D. Alspach, Richard D. Rasmussen, Lloyd L. Ingraham |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Light
Flavin Mononucleotide Stereochemistry Enthalpy Biophysics Flavin mononucleotide Flavin group Calorimetry Ring (chemistry) Photochemistry Models Biological Biochemistry Catalysis chemistry.chemical_compound Luciferases Molecular Biology Bacterial luciferase Bacteria Chemistry Azetines Temperature Cell Biology Excited state Azetidines Thermodynamics |
| Zdroj: | Biochemical and Biophysical Research Communications. 73:465-469 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/0006-291x(76)90730-0 |
| Popis: | 2-Oxo-3-phenyl-1,3-oxazetidine was found to thermally undergo a 2,2-cyclo-reversion reaction with an enthalpy of activation of 30.8 Kcal. This suggests that an oxazetidine fused to a flavin could be the labile light producing intermediate in the bacterial luciferase reaction since the reaction would be favored by ring fusion and the lower excited state of flavin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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