Could art cycles have a detrimental effect on ovarian reserve? A retrospective case control study
| Autor: | Marianna Mariani, Lucia Riganelli, Maria Grazia Porpora, Lucia Merlino, Maria G Piccioni, Daniela Pietrangeli, Capri O, Silvia Franceschetti, Cesare Aragona, Antonella Linari, Giulietta Micara |
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| Rok vydání: | 2020 |
| Předmět: |
Anti-Mullerian Hormone
Reproductive Techniques Assisted medicine.medical_treatment Physiology Group B reproduction 03 medical and health sciences 0302 clinical medicine Statistical significance medicine Humans Ovarian reserve Ovarian Reserve Retrospective Studies 030219 obstetrics & reproductive medicine Assisted reproductive technology infertility ovarian reserve ovulation induction business.industry Case-control study Obstetrics and Gynecology 030220 oncology & carcinogenesis Case-Control Studies Female business Infertility Female Hormone |
| Zdroj: | Minerva ginecologica. 72(2) |
| ISSN: | 1827-1650 |
| Popis: | Background Even if it is supposed damage of repeated ART (assisted reproductive technology) cycles on oocyte pool, there is still no evidence in literature. Aim of the study is to investigate whether infertile women who undergo to several ART cycles can show a lower ovarian reserve measured by AMH (Anti-Mullerian hormone) levels. Methods The study includes 282 infertile women, between 18 and 42 years, and allocated into two groups: 159 women previously submitted to two or more ART cycles (group A) and 123 women never submitted naive to-ART cycles (group B). We tested whether AMH, FSH, LH and E2 levels were significantly different between the two groups, stratifying according to age. Results Regardless to the age ranges bands, the AMH in group A was statistically significant lower than in group B with a statistical significance (P=0.047). In particular women aged over 35 previously submitted to one or more ART cycles showed lower AMH levels, than those paired with age, which had never been treated with ART. Conclusions Despite the limitations of the study, our data demonstrate a reduced AMH levels in women aged over 35 previously submitted to two or more repeated ART-cycles compared to patients never treated before. The strength of this study is the actuality of the topic that has not been discussed before in detail. |
| Databáze: | OpenAIRE |
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