Studies of RAS function in the yeast Saccharomyces cerevisiae
| Autor: | T. Michaeli, J. Nikawa, Jeffrey Field, T. Toda, Daniel Broek, Michael Wigler, K. Ferguson, Scott J. Cameron, Scott Powers, John J. Colicelli |
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| Rok vydání: | 1988 |
| Předmět: |
Fungal protein
Oncogene biology GTP' Genotype G protein Saccharomyces cerevisiae Genes Fungal Molecular Sequence Data biology.organism_classification Biochemistry Molecular biology Saccharomyces Fungal Proteins Genes ras Mutation Genetics ras Proteins Amino Acid Sequence Signal transduction Molecular Biology Peptide sequence Adenylyl Cyclases Signal Transduction |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0091-7451 |
| Popis: | The three mammalian RAS genes, Ha-ras, Ki-ras, and N-ras, are capable of the malignant transformation of cultured animal cells (Barbacid 1987). Mutations in these genes have been linked to a large number of human cancers (Barbacid 1987). These genes encode closely related proteins that bind guanine nucleotides (Scolnick et al. 1979; Shih et al. 1980; Ellis et al. 1981) and are localized to the inner surface of the plasma membrane (Willingham et al. 1980; Papageorge et al, 1982). Normal RAS proteins also slowly hydrolyze GTP (Gibbs et al. 1984; McGrath et al. 1984; Sweet et al. 1984). These properties are similar to those of the G proteins, which has led to the widespread expectation that RAS proteins, like G proteins, are involved in the transduction of membrane signals that are linked to cellular proliferation or differentiation. |
| Databáze: | OpenAIRE |
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