Safety and immunogenicity of Haemophilus influenzae type B-Neisseria meningitidis Group B outer membrane protein complex conjugate vaccine mixed in the syringe with diphtheriatetanus-pertussis vaccine in young Gambian infants
| Autor: | Jim Todd, Joan M. Staub, Leslie C. Jonas, P. P. Vella, A.M. Greenwood, Vincent I. Ahonkhai, Mulholland Ek, Linda J. Lukacs, Brian Greenwood, ChrisAnna M. Mink |
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| Rok vydání: | 1993 |
| Předmět: |
Microbiology (medical)
Haemophilus Infections Whooping Cough medicine.disease_cause Haemophilus influenzae Conjugate vaccine medicine Humans Diphtheria-Tetanus-Pertussis Vaccine Haemophilus Vaccines Tetanus Vaccines Conjugate business.industry Diphtheria Neisseria meningitidis Immunogenicity Polysaccharides Bacterial Antibody titer Infant medicine.disease Antibodies Bacterial Infectious Diseases Membrane protein complex Pediatrics Perinatology and Child Health Immunology Gambia business Bacterial Outer Membrane Proteins |
| Zdroj: | The Pediatric Infectious Disease Journal. 12:632-637 |
| ISSN: | 0891-3668 |
| DOI: | 10.1097/00006454-199308000-00002 |
| Popis: | To ensure compliance and to reduce costs it is important, especially in less developed countries, that programs of child immunization should require as few clinic attendances and as few injections as possible. Therefore we have investigated whether a Haemophilus influenzae type b conjugate vaccine could be given safely and effectively with diphtheria-tetanus-pertussis vaccine (DTP). One hundred twenty-six Gambian infants were given both polyribosylribitol phosphate (PRP)-outer membrane protein complex (PedvaxHIB) and DTP on the same day at 8, 12 and 16 weeks of age; 60 were given the vaccines mixed in the syringe and 66 were given the vaccines separately. To minimize the injection volume the dose of PRP-OMPC used in both groups was 7.5 micrograms, which is half the usual dose. There were no significant differences in anti-PRP antibody titers between the groups after 1, 2 or 3 doses. The geometric mean titers of antibody for the two groups combined were 0.29 micrograms/ml 1 month after the first dose, 1.03 micrograms/ml after the second dose and 1.11 micrograms/ml after the third dose. Concentrations of antibodies to diphtheria, tetanus and pertussis 1 month after the third dose were not significantly different between the two groups. Systemic side effects were reported with equal frequency in the two groups and were similar to those reported elsewhere for DTP. Tenderness at the injection site was more common where the combined injection (0.75 ml) had been given than where DTP alone (0.5 ml) had been given. The main drawback to the use of these 2 vaccines together is the complexity of the mixing procedure used in this clinical trial. |
| Databáze: | OpenAIRE |
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