Imaging of Glioma Tumor with Endogneous Fluoresence Tomography
| Autor: | Subhadra Srinivasan, Brian W. Pogue, Niculae Mincu, Hamid Dehghani, Frederic Leblond, Dax Kepshire, Michael Hutchins, Mario Khayat, Julia A. O'Hara, Summer L. Gibbs-Strauss |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
X-ray microtomography
Transplantation Heterologous Biomedical Engineering Protoporphyrins Fluorescence spectroscopy Article Fluorescence Biomaterials chemistry.chemical_compound Nuclear magnetic resonance Glioma medicine Animals Humans Optical tomography Tomographic reconstruction Photosensitizing Agents Protoporphyrin IX medicine.diagnostic_test business.industry Brain Neoplasms Aminolevulinic Acid X-Ray Microtomography medicine.disease Atomic and Molecular Physics and Optics Electronic Optical and Magnetic Materials Rats chemistry Tomography Nuclear medicine business |
| Popis: | Tomographic imaging of a glioma tumor with endogenous fluorescence is demonstrated using a noncontact single-photon counting fan-beam acquisition system interfaced with microCT imaging. The fluorescence from protoporphyrin IX (PpIX) was found to be detectable, and allowed imaging of the tumor from within the cranium, even though the tumor presence was not visible in the microCT image. The combination of single-photon counting detection and normalized fluorescence to transmission detection at each channel allowed robust imaging of the signal. This demonstrated use of endogenous fluorescence stimulation from aminolevulinic acid (ALA) and provides the first in vivo demonstration of deep tissue tomographic imaging with protoporphyrin IX. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|