The future of HIV prevention: prospects for an effective anti-HIV microbicide
| Autor: | K. Douville, Annalene Nel, Jeremy Nuttall, Saul Walker, William Heyward, Joseph Romano, Caroline Galbreath, Mark Mitchnick, Zeda F. Rosenberg |
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| Rok vydání: | 2007 |
| Předmět: |
Microbiology (medical)
Receptors CXCR4 Anti-HIV Agents Administration Topical Population HIV Infections Disease Outbreaks Acquired immunodeficiency syndrome (AIDS) Microbicide Drug Resistance Viral Medicine Humans Product (category theory) education Licensure education.field_of_study Clinical Trials as Topic Product design business.industry Dendritic Cells medicine.disease Microbicides for sexually transmitted diseases Infectious Diseases Risk analysis (engineering) Drug development CCR5 Receptor Antagonists Anti-Infective Agents Local HIV-1 Reverse Transcriptase Inhibitors business |
| Zdroj: | Infectious disease clinics of North America. 21(1) |
| ISSN: | 0891-5520 |
| Popis: | Topical microbicides are self-administered products for prevention of HIV transmission, and they present one of the most promising strategies for combating the HIV-AIDS epidemic. The development of microbicides is a long and complicated process, with many hurdles that are unique to this class of product, including challenges in product design, in the conduct and design of clinical trials, and in obtaining licensure of a new class of products intended for use almost exclusively in developing countries. Once they have been registered, there are additional challenges to the marketing and distribution of microbicides. An overview of the types of microbicide currently in development, and a summary of the issues and the approaches being taken to address them, are provided. |
| Databáze: | OpenAIRE |
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