Separation of benign and malignant breast lesions using dynamic contrast enhanced MRI in a biopsy cohort
| Autor: | Linda Moy, Claudia Seuss, Ana Paula Klautau Leite, Sungheon Kim, Jin Zhang, Melanie Freed |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
medicine.medical_specialty Biopsy Contrast Media Breast Neoplasms Article 030218 nuclear medicine & medical imaging Lesion 03 medical and health sciences 0302 clinical medicine Breast cancer Image Interpretation Computer-Assisted Parenchyma Image Processing Computer-Assisted medicine Humans Breast MRI Radiology Nuclear Medicine and imaging Breast Aged Retrospective Studies Receiver operating characteristic medicine.diagnostic_test Clinical pathology business.industry Middle Aged medicine.disease Magnetic Resonance Imaging Kinetics Dynamic contrast-enhanced MRI Female Radiology medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Magnetic Resonance Imaging. 45:1385-1393 |
| ISSN: | 1522-2586 1053-1807 |
| DOI: | 10.1002/jmri.25501 |
| Popis: | PURPOSE To assess the diagnostic utility of contrast kinetic analysis for breast lesions and background parenchyma of women undergoing MRI-guided biopsies, for whom standard clinical analysis had failed to separate benign and malignant lesions. MATERIALS AND METHODS This study included 115 women who had indeterminate lesions based on routine diagnostic breast MRI exams and underwent an MRI (3 Tesla) -guided biopsy of one or more lesions suspicious for breast cancer. Breast dynamic contrast-enhanced (DCE)-MRI was performed using a radial stack-of-stars three-dimensional spoiled gradient echo pulse sequence and modified k-space weighted image contrast image reconstruction. Contrast kinetic model analysis was conducted to characterize the contrast enhancement patterns measured in lesions and background parenchyma (BP). The transfer rate (Ktrans ), interstitial volume fraction (ve ), and vascular volume fraction (vp ) estimated from the lesion and BP were used to separate malignant from benign lesions. RESULTS The patients with malignant lesions had significantly (P |
| Databáze: | OpenAIRE |
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