Nordihydroguaiaretic acid autoxidation produces a schisandrin-like dibenzocyclooctadiene lignan
| Autor: | Jennifer Billinsky, Ed S. Krol |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Pharmaceutical Science
Schisandrin Lignans Analytical Chemistry chemistry.chemical_compound Cyclooctanes Drug Discovery polycyclic compounds medicine Organic chemistry Masoprocol Polycyclic Compounds Phenols Pharmacology Lignan Aqueous solution Autoxidation Molecular Structure fungi Organic Chemistry Stereoisomerism Glutathione carbohydrates (lipids) Nordihydroguaiaretic acid Complementary and alternative medicine chemistry Molecular Medicine Oxidation-Reduction medicine.drug |
| Zdroj: | Journal of natural products. 71(9) |
| ISSN: | 1520-6025 |
| Popis: | The lignan meso-nordihydroguaiaretic acid is known to undergo spontaneous oxidation in alkaline solution. In the presence of the trapping agent glutathione, the major oxidation products are consistent with the formation of a meso-nordihydroguaiaretic acid ortho-quinone. In the absence of a trapping agent however, the major oxidation product of meso-nordihydroguaiaretic acid in aqueous solution is a unique, stable schisandrin-like dibenzocyclooctadiene lignan that may be responsible for some of the biological effects of nordihydroguaiaretic acid. |
| Databáze: | OpenAIRE |
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