Identification of a locus on mouse chromosome 3 involved in differential susceptibility to Theiler's murine encephalomyelitis virus-induced demyelinating disease
| Autor: | Stephen D. Miller, Roger W. Melvold, Howard L. Lipton, D M Jokinen, M. C. Dal Canto |
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| Rok vydání: | 1990 |
| Předmět: |
Genotype
Immunology Mice Inbred Strains Locus (genetics) Major histocompatibility complex Microbiology Mice Species Specificity Virology Enterovirus Infections Demyelinating disease medicine Animals Encephalomyelitis Gene Crosses Genetic Genetics Maus Elberfeld virus biology Multiple sclerosis Haplotype Chromosome Mapping biology.organism_classification medicine.disease Cardiovirus Haplotypes Chromosome 3 Insect Science biology.protein Disease Susceptibility Research Article Demyelinating Diseases |
| Zdroj: | Journal of Virology. 64:686-690 |
| ISSN: | 1098-5514 0022-538X |
| DOI: | 10.1128/jvi.64.2.686-690.1990 |
| Popis: | Theiler's virus-induced demyelinating disease results from a chronic infection in the white matter of the central nervous system and provides an excellent model for human multiple sclerosis. Like multiple sclerosis, there are genetic risk factors in disease development, including genes associated with the major histocompatibility complex and with those encoding the beta chain of the T-cell receptor. Comparisons of the susceptible DBA/2 and resistant C57BL/6 strains have indicated an important role for the H-2D locus and for a non-H-2 gene (not involving the beta chain of the T-cell receptor) in differential susceptibility. In the present report, analysis of recombinant-inbred strains (BXD) between the DBA/2 and C57BL/6 strains indicated that this non-H-2 locus is located at the centromeric end of chromosome 3 near (4 +/- 4 centimorgans) the carbonic anhydrase-2 (Car-2) enzyme locus. |
| Databáze: | OpenAIRE |
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