Blood-Borne Cancer Cells – Quo Vadis?
| Autor: | Burkhard Brandt, Feldner Jc, H. Schmitt, Ralph J. Lellé, Alf Beckmann, Axel Semjonow |
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| Rok vydání: | 2000 |
| Předmět: |
Cancer Research
business.industry Clinical Biochemistry Cell Epithelial Cells medicine.disease Pathology and Forensic Medicine Prostate cancer Cytokeratin medicine.anatomical_structure Breast cancer Oncology Antigen Neoplasms Cancer cell Cancer research medicine Adjuvant therapy Humans Keratins Neoplasm Metastasis Stage (cooking) business Biomarkers Neoplasm Staging |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1724-6008 |
| DOI: | 10.1177/172460080001500121 |
| Popis: | The detection of blood-borne cancer cells may help in clinical staging and further understanding of cancer metastasis. We developed a cytokeratin-based immunomagnetic method to isolate epithelium-derived cells from the circulating blood of patients. The number of cell clusters positive for cytokeratin/prostate-specific antigen (PSA) from the peripheral blood of prostate cancer patients and cytokeratin/p185c-erbB-2 from the peripheral blood of breast cancer patients has been related to stage of the disease. Breast cancer patients who presented cytokeratin/p185c-erbB-2-positive cell clusters showed a decrease in such cells under adriamycin adjuvant therapy with Further molecular characterization by a highly sensitive microsatellite multiplex-PCR enabled reproducible detection of microsatellite alterations. The impact of these individually targeted results may contribute to an individual diagnostic and therapeutic strategy. |
| Databáze: | OpenAIRE |
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