Complete deficiency of constitutive heterochromatin on a human chromosome 9
| Autor: | W. L. Gouw, J. M. M. Ypma, Charles H.C.M. Buys |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1979 |
| Předmět: |
Adult
Male Heterozygote Heterochromatin Chromosome 9 Biology chemistry.chemical_compound Pregnancy Genetics Humans Constitutive heterochromatin DAPI Genetics (clinical) Chromosomes Human 6-12 and X Staining and Labeling Infant Newborn Chromosome Karyotype Heterozygote advantage Amniotic Fluid Phenotype Molecular biology chemistry Karyotyping Female |
| Zdroj: | HUMAN GENETICS, 49(2), 129-132. SPRINGER |
| ISSN: | 0340-6717 |
| Popis: | In cultured amniotic fluid cells a mediocentric chromosome 9 appeared to be completely deficient in constitutive heterochromatin when stained with distamycin A and DAPI. In addition, this deficient chromosome was found in a blood cell culture from the father. Both the father and the child after birth were phenotypically normal. Evidently, a considerable heterozygotic deficit of chromosome 9 heterochromatin can be tolerated without affecting the phenotype. The heterochromatin defect was also shown by G11-staining. Distamycin A-DAPI staining is highly reproducible and is recommended as a fluorescent alternative to often less successful G11-methods for the detection of heteromorphism of chromosome 9. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink