Comparative evaluation of the short-term bactericidal potential of a steroid-antibiotic combination versus steroid in the treatment of chronic bacterial blepharitis and conjunctivitis
| Autor: | U Mester, R H Stewart, D G Shulman, J B Sargent |
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| Rok vydání: | 1996 |
| Předmět: |
Male
Administration Topical Antibiotics Anti-Inflammatory Agents Colony Count Microbial Gastroenterology Dexamethasone Eye Infections Bacterial Conjunctivitis Bacterial 0302 clinical medicine Antibacterial agent Polymyxin B Aged 80 and over Blepharitis Aminoglycoside General Medicine Neomycin Middle Aged Anti-Bacterial Agents Drug Combinations Corticosteroid Female Conjunctiva medicine.drug Adult medicine.medical_specialty medicine.drug_class Gram-Positive Bacteria 03 medical and health sciences Double-Blind Method Internal medicine Gram-Negative Bacteria medicine Humans Glucocorticoids Aged business.industry Eyelids Eye infection medicine.disease Ophthalmology Immunology Chronic Disease 030221 ophthalmology & optometry Fluprednisolone Ophthalmic Solutions business 030217 neurology & neurosurgery |
| Zdroj: | European journal of ophthalmology. 6(4) |
| ISSN: | 1120-6721 |
| Popis: | The effects of four days' treatment with topical Maxitrol (neomycin sulphate 3500 IU/mL, polymyxin-B sulphate 6000 IU/mL with dexamethasone 0.1%) were compared with those of Maxidex (dexamethasone 0.1% alone) in a double-masked study in 111 patients with bacterial blepharitis or conjunctivitis, 95 of whom were evaluable for efficacy. The majority of patients (N = 80) had chronic blepharitis. Maxitrol treatment resulted in a significantly greater reduction (90%) in bacterial counts and bacterial eradication (50%) compared with Maxidex (34% and 17% respectively). Maxitrol treatment also produced a significantly greater reduction in conjunctival discharge than did Maxidex, while the treatments were equally effective in alleviating other ocular signs and symptoms. It was concluded that use of a fixed dose combination steroid-antibiotic product was more effective for bacterial control and therapeutic efficacy in the treatment of chronic blepharitis and conjunctivitis patients than treatment with steroid alone. However, in the long-term treatment of chronic blepharitis the well-known toxic problems of neomycin sulphate have to be taken into account. |
| Databáze: | OpenAIRE |
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