Number of lymph nodes examined and prognosis of TNM stage II colorectal cancer
| Autor: | Antonio Mazzeo, Carlo Salvemini, Davide Di Mauro, Giovanni Bader, Gabriele Regina, Luigi Roncoroni, Leopoldo Sarli, Domenico Iusco |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Colorectal cancer Gastroenterology Internal medicine medicine Humans Prospective Studies Stage (cooking) Prospective cohort study Lymph node Survival analysis Aged Neoplasm Staging business.industry Hazard ratio Five-year survival rate Prognosis medicine.disease Survival Analysis Surgery medicine.anatomical_structure Oncology Lymphatic Metastasis Lymph Node Excision Regression Analysis Female Lymph Colorectal Neoplasms business |
| Zdroj: | European Journal of Cancer. 41:272-279 |
| ISSN: | 0959-8049 |
| DOI: | 10.1016/j.ejca.2004.10.010 |
| Popis: | The diagnosis of a lymph node-negative colorectal carcinoma should imply a good prognosis; however, the outcomes for TNM stage II patients remain variable. Few studies have examined the relationship of the number of lymph nodes examined to the prognosis of this stage. The aim of this study was to determine whether the number of lymph nodes examined has an effect on prognosis of a relatively large sample of patients undergoing curative surgery for stage II colorectal cancer at a single institution. Data on patients who underwent surgery for colorectal cancer between January 1980 and April 2000 were prospectively collected in a database. Patients with TNM stage II or stage III tumours who were treated with curative intent were removed. Patients over 80 years of age were excluded from the survival analysis. Survival comparisons were made using Kaplan-Meier curves and the log-rank test. Multivariate analysis was performed using a Cox regression model. A total of 625 cases of TNM stage II cases and, for comparison purposes, 415 stage III cases, were analysed. Lymph node retrieval in stage II cases was affected by the patient's age (P=0.04) and gender (P=0.02), tumour grade (P |
| Databáze: | OpenAIRE |
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