Review article: chronic viral infection in the anti-tumour necrosis factor therapy era in inflammatory bowel disease

Autor:	Cynthia H. Seow, Remo Panaccione, Subrata Ghosh, Gilaad G. Kaplan, Matthew Shale, Carla S. Coffin
Rok vydání:	2010
Předmět:	Opportunistic Infections Inflammatory bowel disease Recurrence Risk Factors medicine Adalimumab Humans Pharmacology (medical) Certolizumab pegol Hepatitis Hepatology Tumor Necrosis Factor-alpha business.industry Gastroenterology Hepatitis C Hepatitis B Inflammatory Bowel Diseases medicine.disease Infliximab Virus Diseases Chronic Disease Practice Guidelines as Topic Immunology Virus Activation Viral disease business Immunosuppressive Agents medicine.drug
Zdroj:	Alimentary Pharmacology & Therapeutics. 31:20-34
ISSN:	1365-2036 0269-2813
DOI:	10.1111/j.1365-2036.2009.04112.x
Popis:	Summary Background Anti-Tumour necrosis factor (TNF) therapy is now well established in the treatment of inflammatory bowel disease and the risk of opportunistic infection is recognized. However, specific considerations regarding screening, detection, prevention and treatment of chronic viral infections in the context of anti-TNF therapy in inflammatory bowel disease are not widely adopted in practice. Aim To provide a detailed and comprehensive review of the relevance of chronic viral infections in the context of anti-TNF therapy in inflammatory bowel disease. Methods Literature search was conducted using Medline, Pubmed and Embase using the terms viral infection, hepatitis, herpes, CMV, EBV, HPV, anti-TNF, infliximab, adalimumab, certolizumab pegol and etanercept. Hepatitis B and C and HIV had the largest literature associated and these have been summarized in Tables. Results Particular risks are associated with the use of anti-TNF drugs in patients with hepatitis B infection, in whom reactivation is common unless anti-viral prophylaxis is used. Reactivation of herpes zoster is the most common viral problem associated with anti-TNF treatment, and may be particularly severe. Primary varicella infection may present with atypical features in patients on anti-TNF. Conclusion Appreciation of risks of chronic viral disease associated with anti-TNF therapy may permit early recognition, prophylaxis and treatment.
Databáze:	OpenAIRE
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