Histone Deubiquitinase OTU1 Epigenetically Regulates DA1 and DA2, Which Control Arabidopsis Seed and Organ Size
| Autor: | Benoît Lacroix, Vitaly Citovsky, Abraham Q. Kohrman, Ido Keren |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
education.field_of_study
Multidisciplinary biology Euchromatin Population Repressor Plant Biology Plant Development food and beverages biology.organism_classification Plant Genetics Article Cell biology Deubiquitinating enzyme Chromatin Histone Arabidopsis biology.protein lcsh:Q Epigenetics education lcsh:Science |
| Zdroj: | iScience, Vol 23, Iss 3, Pp-(2020) iScience |
| ISSN: | 2589-0042 |
| Popis: | Summary Seeds are central to plant life cycle and to human nutrition, functioning as the major supplier of human population energy intake. To understand better the roles of enzymic writers and erasers of the epigenetic marks, in particular, histone ubiquitylation and the corresponding histone modifiers, involved in control of seed development, we identified the otubain-like cysteine protease OTU1 as a histone deubiquitinase involved in transcriptional repression of the DA1 and DA2 genes known to regulate seed and organ size in Arabidopsis. Loss-of-function mutants of OTU1 accumulate H2B monoubiquitylation and such euchromatic marks as H3 trimethylation and hyperacetylation in the DA1 and DA2 chromatin. These data advance our knowledge about epigenetic regulation of the DA1 and DA2 genes by recognizing OTU1 as a member of a putative repressor complex that negatively regulates their transcription. Graphical Abstract Highlights • Histone ubiquitylation regulates transcription of DA1/DA2 that control seed/organ size • OTU1 deubiquitinase is involved in deubiquitylation of the DA1/DA2 chromatin • OTU1 acts as an epigenetic transcriptional repressor of the DA1/DA2 genes • OTU1 is nucleocytoplasmic, indicating involvement in nuclear and cytoplasmic processes Plant Biology; Plant Genetics; Plant Development |
| Databáze: | OpenAIRE |
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