Efficacy of perampanel in a patient with epilepsia partialis continua
| Autor: | Herminia Argente-Escrig, Asier Gómez-Ibáñez, Vicente Villanueva |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
AMPA α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid Efficacy Myoclonic Jerk Antiepileptic drug Epilepsia partialis continua LCM lacosamide Perampanel Article EEG electroencephalogram lcsh:RC321-571 03 medical and health sciences Behavioral Neuroscience chemistry.chemical_compound 0302 clinical medicine Medicine lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry AMPA alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid business.industry AED antiepileptic drug Focal epilepsy medicine.disease MRI - Magnetic resonance imaging 030104 developmental biology Neurology chemistry CZP clonazepam Anesthesia RCT randomized clinical trials PER perampanel LEV levetiracetam Neurology (clinical) business Meningioma MRI magnetic resonance imaging EPC epilepsia partialis continua 030217 neurology & neurosurgery |
| Zdroj: | Epilepsy and Behavior Case Reports, Vol 8, Iss C, Pp 105-107 (2017) Epilepsy & Behavior Case Reports r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe instname |
| ISSN: | 2213-3232 |
| Popis: | Perampanel is the first-in-class selective and noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist. It is authorized in the U.S. and Europe as an add-on antiepileptic drug for partial-onset seizures, and for primary generalized tonic-clonic seizures. Single reports have also indicated a potential efficacy for myoclonic jerks. Here, we report a patient whose drug-resistant epilepsia partialis continua completely resolved after adding perampanel. She has remained seizure-free in an eighteen-month follow-up period. Epilepsia partialis continua reemerged transiently after perampanel was temporarily discontinued, with no recurrence after its reintroduction. Therefore, this effect was reproducible, and suggests that it might be worth trying perampanel in similar settings. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|