Quantifying biological effects of radiation from high-energy linear accelerators on lymphocytes
| Autor: | Csilla Pesznyák, Zsolt Jurányi, Gábor J. Székely, Csaba Polgár, Zsuzsa S Kocsis, Tamás Pócza, Tibor Major, Gyöngyi Farkas, Dalma Mihály |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male High energy Calibration curve Health Toxicology and Mutagenesis Chromatids Radiation Linear particle accelerator 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Biodosimetry Relative biological effectiveness Humans Dosimetry Radiology Nuclear Medicine and imaging Lymphocytes Irradiation Letter to the Editor Chromosome Aberrations Physics Photons business.industry Dose-Response Relationship Radiation biological dosimetry linear accelerator dicentric chromosome flattening filter-free mode 030220 oncology & carcinogenesis Calibration Cytogenetic Analysis Female Particle Accelerators Nuclear medicine business Relative Biological Effectiveness |
| Zdroj: | Journal of Radiation Research |
| ISSN: | 1349-9157 0449-3060 |
| Popis: | The aim of this study was to investigate the radiobiological effects of flattening filter (FF) and flattening filter-free (FFF) modes of linear electron accelerators and to understand whether there is any difference between the effects of these modes. We evaluated the number of chromosome aberrations following irradiation of lymphocytes from healthy volunteers with X-ray photons at two energy levels, 6 and 10 MV; the dose rate ranged between 5.50 and 23.08 Gy/min and absorbed doses ranged between 0.5 and 8 Gy. A 60Co curve was employed for comparison. Metaphases from the lymphocyte cultures were prepared using standard cytogenetic techniques and chromosome analysis was performed. Our results allow the performance of biodosimetry at higher energies and doses than the currently used reference dosimetry. We observed significant differences in aberration frequencies when different irradiation techniques were used. FFF mode has a higher radiobiological effect than the FF mode. Linear-quadratic dose response calibration curves were constructed and relative biological effectiveness (RBE) values were calculated. Average RBE values using 6 MV (5.50 Gy/min) as a reference radiation were 1.28 for 60Co γ irradiation, 1.11 for 6 FFF and 0.79–0.92 for 10 FFF. Since there are compelling differences between radiation modalities in cases of hypofractionation, these results may be even more important in a therapeutic situation. In case of an accidental overdose of a patient, use of the appropriate calibration curves for biodosimetry are also essential for quantifying the overdose. |
| Databáze: | OpenAIRE |
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