Influence of Hypertension on the Survival of Non-Small Cell Lung Cancer Patients with Type 2 Diabetes Mellitus
| Autor: | Bo Zhu, Haixia Long, Xianghua Zeng, Dong Zeng, Chengdu Sun, Jia-Nan Cheng, Cheng Xu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Blood Glucose
Male China medicine.medical_specialty Lung Neoplasms medicine.medical_treatment Kaplan-Meier Estimate 030204 cardiovascular system & hematology Gastroenterology Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Clinical Research Risk Factors Carcinoma Non-Small-Cell Lung Internal medicine Diabetes mellitus Humans Medicine Lung cancer Aged Proportional Hazards Models Retrospective Studies Chemotherapy business.industry Proportional hazards model Incidence Cancer Type 2 Diabetes Mellitus Retrospective cohort study Fasting General Medicine Middle Aged Prognosis medicine.disease Diabetes Mellitus Type 2 030220 oncology & carcinogenesis Hypertension Female business Complication |
| Zdroj: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
| ISSN: | 1643-3750 |
| Popis: | BACKGROUND Hypertension and diabetes mellitus (DM) are both the risk factors for cancer. This study aimed to explore the prognostic value of fasting blood glucose (FBG) and hypertension in type 2 DM (T2DM) patients with advanced non-small cell lung cancer (NSCLC) who had received chemotherapy treatment. MATERIAL AND METHODS There were 181 advanced NSCLC patients with T2DM between 2010 and 2019 included in this study. Their laboratory and clinical data were retrospectively analyzed. The predictive value of FBG and hypertension was evaluated. The Kaplan-Meier method was used to evaluate progression-free survival (PFS). RESULTS The median PFS was 168.0 days (95% CI: 137.9-198.7 days) in patients with FBG ≥7 mmol/L compared to 154.0 days (95% CI: 126.7-181.3 days) for patients with FBG7 mmol/L (hazard ratio [HR]=1.054; 95% CI: 0.7669-1.452; P=0.7447). Median PFS was longer in non-hypertensive patients than in hypertensive patients [179.0 days (95% CI: 137.3-220.7 days) versus 128.0 days (95% CI: 96.3-159.7 days); P=0.0189]. The existence of hypertension (HR=1.478; 95% CI: 1.063-2.055; P=0.020) was an independent predictor for shorter PFS in the multivariate analysis. Decreased hemoglobin was the major adverse event (over 95% patients). The incidence of all grades of adverse reactions was similar between hypertensive and non-hypertensive patients (all P0.05) except diarrhea (P=0.020). CONCLUSIONS Complication of hypertension might confer a poor survival for advanced NSCLC patients with T2DM. Further prospective research is needed to confirm these findings. |
| Databáze: | OpenAIRE |
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