Structure-based design of carboxybiphenylindole inhibitors of the ZipA–FtsZ interaction

Autor:	Karen L. Wheless, Desiree H.H. Tsao, Weidong Ding, Juan C. Alvarez, Alexey Ruzin, Kenneth Foreman, Alan G. Sutherland, Pornpen Labthavikul, Lidia Mosyak, Thomas S. Rush, Peter Petersen, Cynthia Hess Kenny
Rok vydání:	2003
Předmět:	Models Molecular Indoles Molecular Structure biology Stereochemistry Chemistry Escherichia coli Proteins Organic Chemistry Cell Cycle Proteins Biochemistry Protein Structure Tertiary Cytoskeletal Proteins Inhibitory Concentration 50 Structure-Activity Relationship Bacterial Proteins Drug Design biology.protein Structure based Physical and Theoretical Chemistry Binding site Carrier Proteins FtsZ Protein Binding
Zdroj:	Org. Biomol. Chem.. 1:4138-4140
ISSN:	1477-0539 1477-0520
DOI:	10.1039/b312016c
Popis:	Structural features of two weak inhibitors of the ZipA-FtsZ protein-protein interaction which were found to bind to overlapping but different areas of the key binding site were combined in one new series of carboxybiphenyl-indoles with improved inhibitory activity.
Databáze:	OpenAIRE
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