Ionofore antibiotic polynactin produced by Streptomyces sp. 156A isolated from Lake Baikal
| Autor: | E. V. Sukhanova, N. L. Bel’kova, Anton V. Kuzmin, Tatyana A. Shishlyannikova, Sergey M. Shishlyannikov, Irina A. Lipko, G. A. Fedorova |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.drug_class Stereochemistry Gram-positive bacteria Liquid-Liquid Extraction 030106 microbiology Antibiotics Nonactin Microbial Sensitivity Tests Plant Science Gram-Positive Bacteria Tandem mass spectrometry 01 natural sciences Biochemistry Streptomyces Russia Analytical Chemistry Microbiology 03 medical and health sciences chemistry.chemical_compound Tandem Mass Spectrometry Drug Resistance Bacterial medicine biology Strain (chemistry) Organic Chemistry Carbon-13 NMR biology.organism_classification Anti-Bacterial Agents 0104 chemical sciences Lakes 010404 medicinal & biomolecular chemistry chemistry Spectrometry Mass Matrix-Assisted Laser Desorption-Ionization Macrolides Antibacterial activity |
| Zdroj: | Natural Product Research. 31:639-644 |
| ISSN: | 1478-6427 1478-6419 |
| Popis: | The potential antibacterial activity of secondary metabolites produced by Streptomyces sp. 156A isolated from Lake Baikal was investigated. The selective liquid-liquid extraction method was applied to obtain a mixture of nactins (polynactin) produced by the strain. The polynactin consisted of nonactin (3%), monactin (18%), dinactin (36%), trinactin (31%) and tetranactin (12%). The compounds were identified by MS/MS, 1H and 13C NMR methods. The loss of neutral 184 and 198 Da fragments from a sodiated molecular ion, [M + Na]+, of nactins was observed in the MS/MS spectrum. The polynactin was shown to possess the antibiotic activity against Gram-positive strains including opportunistic strains and strains isolated from various ecosystems of Lake Baikal. |
| Databáze: | OpenAIRE |
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