Delivering advanced therapies: the big pharma approach
| Autor: | S Kili, J Imrie, R Haddock, Amol Ketkar, J Tarnowski, L Jespers, D Krishna |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pace of innovation Drug Industry business.industry Genetically engineered Supply chain Genetic Therapy Patient care Product pricing 03 medical and health sciences 030104 developmental biology Biopharmaceutical Risk analysis (engineering) Genetics Molecular Medicine Medicine business Molecular Biology |
| Zdroj: | Gene Therapy. 24:593-598 |
| ISSN: | 1476-5462 0969-7128 |
| DOI: | 10.1038/gt.2017.65 |
| Popis: | After two decades of focused development and some recent clinical successes, cell and gene therapy (CGT) is emerging as a promising approach to personalized medicines. Genetically engineered cells as a medical modality are poised to stand alongside or in combination with small molecule and biopharmaceutical approaches to bring new therapies to patients globally. Big pharma can have a vital role in industrializing CGT by focusing on diseases with high unmet medical need and compelling genetic evidence. Pharma should invest in manufacturing and supply chain solutions that deliver reproducible, high-quality therapies at a commercially viable cost. Owing to the fast pace of innovation in this field proactive engagement with regulators is critical. It is also vital to understand the needs of patients all along the patient care pathway and to establish product pricing that is accepted by prescribers, payers and patients. |
| Databáze: | OpenAIRE |
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