A MELAS Patient Developing Fatal Acute Renal Failure with Lactic Acidosis and Rhabdomyolysis
| Autor: | Riki Okeda, Tetsumasa Kamei, Hisashi Ito, Osamu Tokunaga, Sanae Odake, Shigeru Fukutake |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Encephalopathy Case Report Degeneration (medical) 030204 cardiovascular system & hematology acute renal failure 03 medical and health sciences 0302 clinical medicine Fatal Outcome Mitochondrial myopathy Internal medicine Intensive care Internal Medicine medicine MELAS Syndrome Humans Letters to the Editor Pathological business.industry General Medicine Acute Kidney Injury medicine.disease lactic acidosis Renal pathology Lactic acidosis MELAS Cardiology rhabdomyolysis 030211 gastroenterology & hepatology Acidosis Lactic Autopsy business Rhabdomyolysis |
| Zdroj: | Internal Medicine |
| ISSN: | 1349-7235 |
| Popis: | We herein present a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS), who developed serious acute renal failure with lactic acidosis, followed by rhabdomyolysis. Despite receiving intensive care, he suffered multiple cardiopulmonary arrests and died 10 days after presentation due to a sudden deterioration of his symptoms. Renal pathology revealed diffuse tubular necrosis with interstitial edema and tubular dilatation on light microscopy, and a severe degeneration of intracellular organelles on electron microscopy. These pathological findings could have resulted from multiple cardiopulmonary arrests; however, we must be aware of the extremely rare but sudden occurrence of these fatal conditions in MELAS patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|