Cytochrome P4501A1 and Glutathione S-Transferase M1 Genotypes as Risk Factors for Prostate Cancer in Japan
| Autor: | Haruo Ito, Juichi Kawamura, Kazuo Fukutome, Ryuichi Yatani, Mariko Murata, Minako Nagao, Yoshinobu Kubota, Masatoshi Watanabe, Taizo Shiraishi |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Genotype Gastroenterology Prostate cancer Risk Factors Prostate Internal medicine Cytochrome P-450 CYP1A1 Humans Medicine Radiology Nuclear Medicine and imaging Allele P-Chloroamphetamine Genotyping Aged Glutathione Transferase Aged 80 and over Polymorphism Genetic biology business.industry Prostatic Neoplasms General Medicine medicine.disease Molecular biology Glutathione S-transferase medicine.anatomical_structure Oncology Relative risk biology.protein business |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1465-3621 0368-2811 |
| DOI: | 10.1093/jjco/28.11.657 |
| Popis: | Background: The p53 mutation spectrum of prostate cancers developing in Japan indicates a role for environmental factors. This suggests there might be differences in susceptibility due to geneticpolymorphisms in metabolic activation enzyme genes. We analyzed genetic polymorph isms of the xenobiotic-metabolizing enzymes, CYP1A 1and GSTM1. Method: Genotyping of CYP1A 1andGSTM1 wasinvestigated byusing allele-specific PCR in 115 prostate cancer (PCa) patients and 204 control patients. Results: The CYP1A 1 Val/Val genotype significantly increased the riskfor PCa (OR =2.6; 95% CI = 1.11-6.25) and the lie/Valgenotype showed a similar tendency (OR = 1.4; CI =0.86-2.29). Individuals with the GSTM1 (0/0) genotype demonstrated a slightly increased risk (OR = 1.3; CI = 0.82-2.04). The combination of the CYP1A 1 Val allele and GSTM1 (0/0) genotype was associated with a higherrisk (OR= 2.3; CI = 1.18-4.48) thanthe CYP1A 1 Valallele alone. When caseswereanalyzed by age at initial diagnosis, the relative risks withboththe CYP1A 1 Valallele and the GSTM1 (0/0) genotype were higherin the young group than in the old group(CYP1A1; OR =1.7, CI =0.89-3.17: GSTM1; OR=1.6, CI =0.84-2.99). Thefrequency of the GSTM1 (0/0) genotype was also higher in patients with advanced stage disease. In stage 0, the OR was 1.7 with a CI of 0.93-3.17 and in stages A and B, the OR was 0.8 with a CI of 0.40-1.62. Conclusions: These results suggest that CYP1A 1 and GSTM1 polymorphisms are linked to a propensity for PCadevelopment. |
| Databáze: | OpenAIRE |
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