Adverse outcome pathway (AOP): α2u-globulin nephropathy and kidney tumors in male rats

Autor:	Katy O. Goyak, Satinder S. Sarang, A. Franzen, Susan J. Borghoff, Jessica P. Ryman-Rasmussen
Rok vydání:	2022
Předmět:	Male Adverse Outcome Pathways Humans Animals Toxicology Risk Assessment United States Kidney Neoplasms Rats
Zdroj:	Critical reviews in toxicology. 52(5)
ISSN:	1547-6898
Popis:	The National Research Council's vision of using adverse outcome pathways (AOPs) as a framework to assist with toxicity assessment for regulatory requirements of chemical assessment has continued to gain traction since its release in 2007. The need to expand the AOP knowledge base has gained urgency, with the U.S. Environmental Protection Agency's directive to eliminate reliance on animal toxicity testing by 2035. To meet these needs, our goal was to elucidate the AOP for male-rat-specific kidney cancer. Male-rat-specific kidney tumors occur through the ability of structurally diverse substances to induce α2u-globulin nephropathy (α2u-N), a well-studied mode of action (MoA) not relevant in humans that results in kidney tumor formation in male rats. An accepted AOP may help facilitate the differentiation from other kidney tumors MoAs. Following identification and review of relevant
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::178dbd5716f095676987910e11cc1cf0 https://pubmed.ncbi.nlm.nih.gov/35862579 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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