Metabolic effects of dietary stearic acid in mice: changes in the fatty acid composition of triglycerides and phospholipids in various tissues
| Autor: | Andrea Bonanome, Michael J. Bennett, Scott M. Grundy |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
Palmitic Acid Phospholipid Oleic Acids Palmitic Acids Kidney Palmitic acid Mice chemistry.chemical_compound Stearate Animals Food science Lung Phospholipids Triglycerides chemistry.chemical_classification Triglyceride Cholesterol Myocardium Fatty Acids Fatty acid Diet Mice Inbred C57BL Oleic acid Adipose Tissue Liver chemistry Biochemistry Female lipids (amino acids peptides and proteins) Stearic acid Cardiology and Cardiovascular Medicine Spleen Stearic Acids Oleic Acid |
| Zdroj: | Atherosclerosis. 94:119-127 |
| ISSN: | 0021-9150 |
| Popis: | The fatty acid patterns of triglycerides and phospholipids extracted from adipose tissue, liver, heart, kidney, spleen, and lung of 3 groups of C57BL/6 mice were determined after feeding diets rich in palmitic acid (16:0) (high palmitic: 16:0 = 45.1% of total fatty acids), stearic acid (18:0) (high stearic: 18:0 = 42.9% of total fatty acids) and oleic acid (18:1) (high oleic: 18:1 = 79.7% of total fatty acids) for 9 months. Triglyceride content of adipose, liver, heart, kidney, lung and spleen tissues was significantly enriched in palmitic acid in mice fed the high palmitic diet (range among all tissues: 19.9% +/- 0.2% to 29.0% +/- 1.9% of total fatty acids) and in oleic acid in mice fed the high oleic diet (range 56.0% +/- 1.9% to 71.6% +/- 1.2%). The stearic acid content of organ triglycerides in mice fed the high stearic diet ranged from 3.7% +/- 0.3% to 10.8% +/- 1.2%; however, the content of oleic acid on this diet (range: 57.0% +/- 1.8% to 71.4% +/- 1.7%) was similar to the one observed in mice fed the high oleic diet. In all organs, phospholipids had a significantly higher percentage of stearic acid (range: 23.5% +/- 0.9% to 51.5% +/- 6.6%) than triglycerides, regardless of diet. To evaluate the production of oleate from stearate and palmitate, 2 groups of mice were fed the high palmitic and the high stearic diets for 1 week and then injected intravenously with [1-14C]palmitate and [1-14C]stearate and the amount of labelled oleate in liver triglycerides was measured.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|