Accuracy assessment of a potential clinical use of navigation-guided intra-operative liver metastasis brachytherapy—a planning study
| Autor: | Daniel Candinas, Evelyn Herrmann, Peter Manser, Michael K. Fix, G. Toporek, Daniel M. Aebersold, Stefan Weber, K. Loessl, D. Terribilini |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Image guidance medicine.medical_treatment Brachytherapy 610 Medicine & health 030218 nuclear medicine & medical imaging Metastasis Intraoperative Period Liver metastases 03 medical and health sciences 0302 clinical medicine Fiducial Markers medicine Humans Combined Modality Therapy Radiology Nuclear Medicine and imaging Radiotherapie Retrospective Studies Leber Radiotherapy Common bile duct Phantoms Imaging business.industry Radiotherapy Planning Computer-Assisted Liver Neoplasms Radiotherapy Dosage Retrospective cohort study Lebermetastasen medicine.disease Ablation Radiation therapy medicine.anatomical_structure Liver Oncology 030220 oncology & carcinogenesis Bildführung Feasibility Studies Original Article Radiology Tomography X-Ray Computed Fiducial marker business Brachytherapie Radiotherapy Image-Guided |
| Zdroj: | Herrmann, Evelyn; Terribilini, Dario; Manser, Peter; Fix, Michael; Toporek, G.; Candinas, Daniel; Weber, S.; Aebersold, Daniel; Lössl, Kristina (2018). Accuracy assessment of a potential clinical use of navigation-guided intra-operative liver metastasis brachytherapy—a planning study. Strahlentherapie und Onkologie, 194(11), pp. 1030-1038. Springer 10.1007/s00066-018-1334-y Strahlentherapie Und Onkologie |
| DOI: | 10.1007/s00066-018-1334-y |
| Popis: | For patients with inoperable liver metastases, intra-operative liver high dose-rate brachytherapy (HDR-BT) is a promising technology enabling delivery of a high radiation dose to the tumor, while sparing healthy tissue. Liver brachytherapy has been described in the literature as safe and effective for the treatment of primary or secondary hepatic malignancies. It is preferred over other ablative techniques for lesions that are either larger than 4 cm or located in close proximity to large vessels or the common bile duct. In contrast to external beam radiation techniques, organ movements do not affect the size of the irradiated volume in intra-operative HDR-BT and new technical solutions exist to support image guidance for intra-operative HDR-BT. We have retrospectively analyzed anonymized CT datasets of 5 patients who underwent open liver surgery (resection and/or ablation) in order to test whether the accuracy of a new image-guidance method specifically adapted for intra-operative HDR-BT is high enough to use it in similar situations and whether patients could potentially benefit from navigation-guided intra-operative needle placement for liver HDR-BT. |
| Databáze: | OpenAIRE |
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