Dose-dependent effect of human milk on Bronchopulmonary dysplasia in very low birth weight infants
| Autor: | Mei Xue, Sannan Wang, Lingling Zhu, Shuang-Shuang Li, Yuelan Ma, Jun Wan, Rui Cheng, Yujie Yin, Yue Wu, Yan Gao, Xiaoyi Deng, Liang-Rong Han, Jun Wang, Ming-Fu Wu, Qianqian Li, Jin-Jun Zhou, Shuping Han, Shanyu Jiang, Wenjuan Tu, Yan Xu, Weiyuan Wang, Xiaoguang Yin, Yu Qiao, Qin Zhou, Zhangbin Yu, Jinxiu Wang, Rongping Zhu, Xiaoqing Chen |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
China Complications Breastfeeding Very low birth weight Gestational Age 03 medical and health sciences 0302 clinical medicine 030225 pediatrics medicine Birth Weight Humans Infant Very Low Birth Weight 030212 general & internal medicine Retrospective Studies Milk Human business.industry Obstetrics Human milk lcsh:RJ1-570 Infant Newborn Infant lcsh:Pediatrics Retrospective cohort study Odds ratio medicine.disease Bronchopulmonary dysplasia Confidence interval Low birth weight Pediatrics Perinatology and Child Health Necrotizing enterocolitis Gestation Female medicine.symptom business Infant Premature Research Article |
| Zdroj: | BMC Pediatrics BMC Pediatrics, Vol 20, Iss 1, Pp 1-8 (2020) |
| ISSN: | 1471-2431 0345-3502 |
| Popis: | Background and aim Human milk has potential protective effects against bronchopulmonary dysplasia (BPD). However, studies on the association between the dose of human milk and BPD in China are limited. This study aimed to evaluate the dose-dependent effects of human milk on BPD and other neonatal morbidities in very low birth weight (VLBW) infants. Methods This retrospective cohort study of preterm infants was conducted on preterm infants of gestational age ≤ 34 weeks and birth weight Results Of 964 included infants, 279 (28.9%) received exclusive preterm formula, 128 (13.3%) received 1–24 ml/(kg · day), 139 (14.4%) received 25–49 ml/(kg · day), and 418 (43.4%) received ≥50 ml/(kg · day) human milk for the first 4 weeks of life. Compared with infants receiving exclusive formula, those receiving the highest volume of human milk daily [≥50 mL/(kg · day)] had lower incidences of BPD [27.5% in ≥50 mL/(kg · day) vs 40.1% in 0 mL/(kg · day) human milk, P = 0.001)], moderate and severe BPD [8.9% in ≥50 mL/(kg · day) vs 16.1% in 0 mL/(kg · day), P = 0.004], necrotizing enterocolitis [NEC; 3.8% in ≥50 mL/(kg · day) vs 10.8% in 0 mL/(kg · day), P = 0.001], late-onset sepsis [LOS; 9.3% in ≥50 mL/(kg · day) vs 19.7% in 0 mL/(kg · day), P P Conclusions A daily threshold amount of ≥50 ml/(kg · day) human milk in the first 4 weeks of life was associated with lower incidence of BPD as well as NEC, LOS, and EUGR in VLBW infants. Trial registration ClinicalTrials.gov Identifier: NCT03453502. Registration date: March 5, 2018. This study was retrospectively registered. |
| Databáze: | OpenAIRE |
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