Mollenynes B–E from the Marine Sponge Spirastrella mollis. Band-Selective Heteronuclear Single Quantum Coherence for Discrimination of Bromo–Chloro Regioisomerism in Natural Products
| Autor: | Brendan M. Duggan, Tadeusz F. Molinski, Xiao Wang |
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| Rok vydání: | 2015 |
| Předmět: |
Biological Products
biology Chemistry Extramural Stereochemistry Molecular Conformation Stereoisomerism General Chemistry Carbon-13 NMR biology.organism_classification Biochemistry Catalysis Molecular conformation Porifera Sponge Colloid and Surface Chemistry Nuclear magnetic resonance Animals Quantum Theory Chlorohydrins Heteronuclear single quantum coherence spectroscopy |
| Zdroj: | Journal of the American Chemical Society. 137:12343-12351 |
| ISSN: | 1520-5126 0002-7863 |
| Popis: | Four new chlorobromohydrins, mollenynes B-E, were isolated from the marine sponge Spirastrella mollis collected from Hogsty Reef, Bahamas. Their structures were elucidated by integrated analysis of NMR, MS, and computational methods. A high-resolution band-selective HSQC experiment was developed to identify (13)C NMR signals in samples at the nanomole-scale that arise from Cl-substituted (13)C by exploiting the (35)Cl/(37)Cl isotope shift. |
| Databáze: | OpenAIRE |
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