Elevated Levels of Both Cardiomyocyte Membrane and Myofibril Damage Markers Predict Adverse Outcomes in Patients With Chronic Heart Failure
| Autor: | Yasuyuki Kitahara, Koichi Setsuta, Teruo Takano, Taminori Ohbayashi, Masato Arau, Yoshihiko Seino, Kyoichi Mizuno |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Cardiovascular event medicine.medical_specialty Cardiac troponin Adverse outcomes Fatty Acid-Binding Proteins Myofibrils Troponin T Internal medicine medicine Humans Myocytes Cardiac In patient Aged Proportional Hazards Models Heart Failure business.industry Cell Membrane General Medicine Middle Aged Prognosis musculoskeletal system medicine.disease Increased risk Case-Control Studies Heart failure Cardiology Female lipids (amino acids peptides and proteins) Cardiology and Cardiovascular Medicine Myofibril business Fatty Acid Binding Protein 3 Biomarkers |
| Zdroj: | Circulation Journal. 72:569-574 |
| ISSN: | 1347-4820 1346-9843 |
| DOI: | 10.1253/circj.72.569 |
| Popis: | BACKGROUND Recent studies have shown the presence of ongoing myocardial damage in patients with chronic heart failure (CHF) detected by myofibril and membrane damage markers, cardiac troponin T (TnT) and heart-type fatty acid-binding protein (H-FABP), which identifies patients at increased risk of a future cardiac event (CE: death or rehospitalization because of worsening CHF). There is a difference between TnT and H-FABP in their release kinetics following myocardial damage. METHODS AND RESULTS TnT and H-FABP were measured in 103 patients with CHF and in 31 controls. Patients were classified into 4 groups based on detectable (>or=0.01 ng/ml) or undetectable TnT (TnT+ or TnT-) and H-FABP >or= or |
| Databáze: | OpenAIRE |
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