Disturbance of B-vitamin status in people with type 2 diabetes in Indonesia--link to renal status, glycemic control and vascular inflammation
| Autor: | Naila Rabbani, Paul J. Thornalley, Antonysunil Adaikalakoteswari, Askandar Tjokroprawiro, John M F Adam, Sarwono Waspadji, Sri Hartini K. S. Kariadi |
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| Rok vydání: | 2011 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Endocrinology Diabetes and Metabolism Type 2 diabetes Diabetic nephropathy chemistry.chemical_compound Endocrinology Internal medicine Diabetes mellitus Internal Medicine Medicine Albuminuria Humans Diabetic Nephropathies Thiamine Vascular Diseases Inflammation business.industry General Medicine Thiamine monophosphate medicine.disease B vitamins chemistry Diabetes Mellitus Type 2 Indonesia Vitamin B Complex medicine.symptom business Thiamine pyrophosphate |
| Zdroj: | Diabetes research and clinical practice. 95(3) |
| ISSN: | 1872-8227 0168-8227 |
| Popis: | Background: Diabetes is associated with mishandling of thiamine in the kidney and development of diabetic nephropathy. The aim of this study is to assess the disturbance of thiamine and other B-vitamin status of patients with type 2 diabetes in Indonesia.\ud \ud Methods: One hundred and fifteen patients with type 2 diabetes with and without microalbuminuria or albuminuria and 39 healthy people were recruited. After a 2-month washout period for B-vitamin supplementation, markers of vitamins B1, B6, B9 and B12, were determined.\ud \ud Results: Fractional excretion of thiamine (22.8 versus 33.5%; P < 0.05) and urinary excretion of the vitamin B6 degradation product 4-pyridoxic acid (0.081 versus 0.133 μmol/g creatinine, P < 0.001) was increased in patients with type 2 diabetes with respect to healthy controls. There was also increased total plasma cobalamin (398 versus 547 pmol/l, P < 0.001) and holotranscobalamin (74 versus 97 pmol/l, P < 0.001) in patients with type 2 diabetes. In multiple regression analysis these were linked to HbA1c, duration of diabetes and systolic blood pressure, and fasting plasma glucose, folate and C-reactive protein, respectively.\ud \ud Conclusions: There was renal mishandling of thiamine, increased degradation of vitamin B6 and cytosolic metabolic resistance to vitamin B12 in patients with type 2 diabetes in Indonesia. |
| Databáze: | OpenAIRE |
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