Prevalence of high-risk HPV and associated risk factors in cases of cervical carcinoma in Tamil Nadu, India
| Autor: | Santhanam Shanmughapriya, Ganesan Senthikumar, Sumathy Sanmugham, Kalimuthusamy Natarajaseenivasan, Bhudev C. Das, Krishnakumar Vinodhini |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
medicine.medical_specialty Prevalence India Uterine Cervical Neoplasms Gravidity Polymerase Chain Reaction Young Adult Pregnancy Risk Factors Medicine Humans Mass Screening Young adult Aged Cervical cancer Gynecology Human papillomavirus 16 business.industry Obstetrics Papillomavirus Infections Case-control study HPV infection Age Factors Obstetrics and Gynecology General Medicine Middle Aged medicine.disease Uterine Cervical Dysplasia Vaccination Dysplasia Case-Control Studies DNA Viral Female business |
| Zdroj: | International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. 119(3) |
| ISSN: | 1879-3479 |
| Popis: | article i nfo Article history: Objective: To assess the prevalence of HPV infection among women with cervical cancer in Tiruchirapalli, Tamil Nadu, India. Methods: A case-control study was conducted with 246 women with cervical cancer and 257 control participants aged between 20 and 70 years. The presence of HPV DNA was determined using the MY09/11 PCR protocol, the GP5 + /6 + PCR protocol, and type-specific PCR-based assays. Results: The overall HPV prevalence was 54.9% and HPV 16 was the most prevalent type. The women the most vul- nerable for HPV infection were those aged 41 to 60 years. The major contributing risk factors for cervical cancer were having had 3 or more pregnancies (OR 19.2; 95% CI, 10.78-10.16); harboring high-risk HPV DNA (OR 15.3; 95% CI, 9.81-23.8); being a manual worker (OR 14.9; 95% CI, 9.62-23.08); being illiterate (OR 8.28; 95% CI, 5.51-12.43); and having never been screened for cervical dysplasia (OR 6.70; 95% CI, 10.78-34.44). Conclusion: The present report on the overall and type-specific prevalence rates and risk bur- den of HPV infection in Tamil Nadu confirms that screening and vaccination programs are urgently needed in this state to overcome the burden of HPV-associated cervical cancer. |
| Databáze: | OpenAIRE |
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