Human papillomavirus infection and P53 codon 72 genotypes in a hispanic population at high-risk for cervical cancer
Autor: | Qin He, Peter L. Rady, Stephen K. Tyring, Sabine Woeber, Andrea L. Fuessel Haws, Susan P. Fisher-Hoch, Miroslava Gomez, Joseph B. McCormick, Noe Garza, Yvonne Gomez, Lifang Zhang, James J. Grady |
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Rok vydání: | 2005 |
Předmět: |
Adult
Adolescent Genotype Population Uterine Cervical Neoplasms Malignancy medicine.disease_cause Underserved Population Risk Factors Virology Humans Medicine Genetic Predisposition to Disease education Papillomaviridae Aged Cervical cancer education.field_of_study business.industry Papillomavirus Infections virus diseases Hispanic or Latino Middle Aged medicine.disease Genotype frequency Infectious Diseases Female Tumor Suppressor Protein p53 business Carcinogenesis Nested polymerase chain reaction |
Zdroj: | Journal of Medical Virology. 77:265-272 |
ISSN: | 1096-9071 0146-6615 |
Popis: | Cervical cancer mortality is high in Texas, especially among Hispanic women living in south Texas and adjacent Mexico. Though human papillomavirus (HPV) infection has a causal role in the development of cervical cancer, there are no published data on the prevalence of HPV genotypes in this underscreened region. We studied 398 Hispanic women on both sides of the border along the lower Rio Grande River to determine the prevalence of HPV genotypes and risk factors for cervical cancer. Using a nested PCR system HPV was detected in 62% of cervical specimens, including all the known high-risk HPV genotypes, with HPV16 and HPV18 the most frequent (30.6% and 23.0%, respectively). Multiple infections were common (29.4% of the infected specimens), and where this occurred we were more likely to find high-risk HPV genotypes. We examined host p53 codon 72 genotype frequencies and found that patients with cervical abnormalities and women with HPV16 and HPV18 infections had a lower genotype frequency of the homozygous (AA) previously reported to be associated with cervical cancer, than uninfected women with no abnormalities. In this US/Mexico border population high rates of potentially oncogenic HPV viruses and multiple infections are consistent with observed elevated cervical cancer rates. These data are further evidence that in this underserved population HPV infections are associated with high rates of malignancy, but that host p53 genotypic variations are unlikely to be primary factors in oncogenesis. J. Med. Virol. 77:265–272, 2005. © 2005 Wiley-Liss, Inc. |
Databáze: | OpenAIRE |
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