The rate of progression of type 2 diabetes mellitus to end stage renal disease - A single centred retrospective study from Malaysia
| Autor: | Cheng Hoon Yap, Yen Ping Ng, Ganesh Pandian Balasubramanian, Chia Ying Lau, Ramadan Ahmed, Guat See Ooi |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Angiotensin-Converting Enzyme Inhibitors Type 2 diabetes 030204 cardiovascular system & hematology urologic and male genital diseases End stage renal disease Diabetic nephropathy 03 medical and health sciences Angiotensin Receptor Antagonists 0302 clinical medicine Diabetes mellitus Internal medicine Internal Medicine Medicine Humans Diabetic Nephropathies 030212 general & internal medicine Dialysis Aged Retrospective Studies business.industry Malaysia Type 2 Diabetes Mellitus Retrospective cohort study General Medicine Middle Aged medicine.disease Diabetes Mellitus Type 2 ACE inhibitor Disease Progression Kidney Failure Chronic Female business medicine.drug |
| Zdroj: | Diabetesmetabolic syndrome. 12(6) |
| ISSN: | 1878-0334 |
| Popis: | Introduction In Malaysia, 61% of dialysis cases are secondary to diabetes. To date, we are still lacking of data on the rate of progression of type 2 diabetes mellitus (T2DM) to end stage renal disease (ESRD) in Malaysia. Materials and methods This was a retrospective study conducted at nephrology unit of a tertiary hospital in Kedah. All diabetic ESRD patients who fulfilled the inclusion criteria were identified and recruited for analysis. Results The mean duration of DM to ESRD was found to be 14.37 ± 4.42 years. Mean duration for the onset of diabetic nephropathy was 8.73 ± 3.37 years. There was a relative short duration from diabetic nephropathy to ESRD noted, which was 5.63 ± 2.06 years. The mean duration of DM to ESRD for patients receiving RAAS blocker was found to be 18.23 ± 2.38 years as compared to 11.41 ± 2.94 years for those who did not (95% CI: -0.64 to -2.46). For different type of RAAS blockers, namely ACE inhibitor and angiotensin receptor blocker (ARB), there was no significant difference observed pertaining to mean duration of DM to ESRD; 17.89 ± 1.97 years for ACEi and 19.00 ± 4.16 years for ARB (95% CI: -4.74 to 2.52). Discussion Time frame from diabetic nephropathy to ESRF among Malaysian population was shorter as compared to findings from other countries with an average period of 15 to 25 years. RAAS blockers should be initiated early in diabetic patients. |
| Databáze: | OpenAIRE |
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