Design and in vitro evaluation of a novel poly(methacrylic acid)/metronidazole antibacterial nanogel as an oral dosage form
| Autor: | Lina Guo, Zhiyu Chen, Haicheng Li, Qiu Zhong, Chen Yuhui, Changhui Cai, Guo Huixin, Chen Liang, Shu Yang, Tao Chen, Zhou Lin, Xian-En Zhang |
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| Rok vydání: | 2013 |
| Předmět: |
Poly(methacrylic acid)
Time Factors Ethylene glycol dimethacrylate Administration Oral Nanogels Microbial Sensitivity Tests Dosage form Polyethylene Glycols Bacteroides fragilis chemistry.chemical_compound Colloid and Surface Chemistry Polymethacrylic Acids Cell Line Tumor Metronidazole Polymer chemistry Humans Polyethyleneimine Physical and Theoretical Chemistry Particle Size Cytotoxicity Dosage Forms biology Cell Death Surfaces and Interfaces General Medicine biology.organism_classification Anti-Bacterial Agents Kinetics chemistry Methacrylic acid Antibacterial activity Biotechnology Nuclear chemistry Nanogel |
| Zdroj: | Colloids and surfaces. B, Biointerfaces. 118 |
| ISSN: | 1873-4367 |
| Popis: | To overcome the undesirable side-effects of metronidazole (MTZ), ethylene glycol dimethacrylate is used as the cross-linker, and a series of poly(methacrylic acid) (PMAA) nanogels were prepared to load the MTZ. We investigated the morphology, size, in vitro release property in the simulated gastrointestinal medium, long-term antibacterial performance against Bacteroides fragilis, cytotoxicity, stability and activity of this novel MTZ/PMAA nanogel. The results indicate that the MTZ/PMAA nanogel sustained the release of MTZ in long-term antibacterial activity in the simulated gastrointestinal medium. This MTZ/PMAA nanogel exhibits less cytotoxicity than MTZ alone, suggesting that MTZ/PMAA nanogel is a more useful dosage form than MTZ for mild-to-moderate Clostridium difficile infections. The novel aspects of this study include the synthesis of a nanogel and the three-phase study of the release profile, which might be useful for other researchers in this field. |
| Databáze: | OpenAIRE |
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