Novel Cationic Quinazolin-4(3H)-one Conjugated Fullerene Nanoparticles as Antimycobacterial and Antimicrobial Agents
| Autor: | Shobhana K. Menon, Nikunj N. Valand, Manishkumar B. Patel, Nishith R. Modi, Uma Harikrishnan |
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| Rok vydání: | 2013 |
| Předmět: |
Antifungal Agents
Surface Properties Stereochemistry medicine.drug_class Antitubercular Agents Pharmaceutical Science Microbial Sensitivity Tests Gram-Positive Bacteria Antimycobacterial Microscopy Electron Transmission Cations Candida albicans Gram-Negative Bacteria Drug Discovery medicine Moiety biology Chemistry Cationic polymerization Mycobacterium tuberculosis biology.organism_classification medicine.disease Antimicrobial Anti-Bacterial Agents Aspergillus Drug Design Quinazolines Nanoparticles Fullerenes Klebsiella pneumonia Antibacterial activity Aspergillus clavatus |
| Zdroj: | Archiv der Pharmazie. 346:210-220 |
| ISSN: | 0365-6233 |
| DOI: | 10.1002/ardp.201200371 |
| Popis: | A series of novel cationic fullerene derivatives bearing a substituted-quinazolin-4(3H)-one moiety as a side arm were synthesized using the 1,3-dipolar cycloaddition reaction of C60 with azomethine ylides generated from the corresponding Schiff bases of substituted quinazolinones. The synthesized compounds 5a-f were characterized by elemental analysis, FT-IR, 1H NMR, 13C NMR, and ESI-MS and screened for their antibacterial activity against Mycobacterium tuberculosis (H37RV) and antimicrobial activity against selected Gram-positive (Staphylococcus aureus and S. pyogenes) and Gram-negative (Pseudomonas aeruginosa, Klebsiella pneumonia and Escherichia coli) bacterial and fungal strains (Candida albicans, Aspergillus clavatus, and A. niger), respectively. All the compounds exhibited significant activity, with the most effective compounds having MIC values and zones of inhibition comparable to those of standard drugs. |
| Databáze: | OpenAIRE |
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