Serum Thiols as a Biomarker of Disease Activity in Lupus Nephritis
| Autor: | Giselle Katiane Bonfim Bacelar de Souza, Pritesh Lalwani, Luiz Fernando de Souza Passos, Antonio Luiz Boechat, Domingos Savio Nunes de Lima, Emerson Silva Lima |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Science Lupus nephritis Renal function Kidney Function Tests Severity of Illness Index chemistry.chemical_compound immune system diseases medicine Humans Lupus Erythematosus Systemic Sulfhydryl Compounds skin and connective tissue diseases Creatinine Multidisciplinary Lupus erythematosus Systemic lupus erythematosus business.industry medicine.disease Lupus Nephritis Cross-Sectional Studies ROC Curve chemistry Renal pathology Immunology Medicine Biomarker (medicine) Female business Nephritis Biomarkers Research Article |
| Zdroj: | PLoS ONE PLoS ONE, Vol 10, Iss 3, p e0119947 (2015) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0119947 |
| Popis: | Lupus Nephritis (LN) develops in more than half of the Systemic Lupus Erythematous (SLE) patients. However, lack of reliable, specific biomarkers for LN hampers clinical management of patients and impedes development of new therapeutics. The goal of this study was to investigate whether oxidative stress biomarkers in patients with SLE is predictive of renal pathology. Serum biochemical and oxidative stress markers were measured in patients with inactive lupus, active lupus with and without nephritis and compared to healthy control group. To assess the predictive performance of biomarkers, Receiver Operating Characteristic (ROC) curves were constructed and cut-offs were used to identify SLE patients with nephritis. We observed an increased oxidative stress response in all SLE patients compared to healthy controls. Among the several biomarkers tested, serum thiols had a significant inverse association with SLE Disease Activity Index (SLEDAI). Interestingly, thiols were able too aptly differentiate between SLE patients with and without renal pathology, and serum thiol levels were not affected by immunosuppressive drug therapy. The decreased thiols in SLE correlated significantly with serum creatinine and serum C3 levels. Further retrospective evaluation using serum creatinine or C3 levels in combination with thiol's cutoff values from ROC analysis, we could positively predict chronicity of renal pathology in SLE patients. In summary, serum thiols emerge as an inexpensive and reliable indicator of LN, which may not only help in early identification of renal pathology but also aid in the therapeutic management of the disease, in developing countries with resource poor settings. |
| Databáze: | OpenAIRE |
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