Antitumor Effect and Toxicity of an Albumin-Paclitaxel Nanocarrier System Constructed via Controllable Alkali-Induced Conformational Changes
| Autor: | Ying Lu, Canping Huang, Guangming Gong, Hua Su, Hao Tang, Shudong Wang, Qinqin Pan, Jian Zhang, Yanli An, Kaikai Wang, Yongjun Jiao, Weimin Dai, Ahu Yuan |
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| Rok vydání: | 2021 |
| Předmět: |
Chemistry
0206 medical engineering technology industry and agriculture Biomedical Engineering Albumin Nanoparticle 02 engineering and technology 021001 nanoscience & nanotechnology Alkali metal 020601 biomedical engineering Combinatorial chemistry Nanomaterials Biomaterials chemistry.chemical_compound Paclitaxel Toxicity sense organs Nanocarriers skin and connective tissue diseases 0210 nano-technology |
| Zdroj: | ACS biomaterials scienceengineering. 5(4) |
| ISSN: | 2373-9878 |
| Popis: | Various strategies have been developed to construct albumin nanomaterials via biophysical or chemical changes. In this work, a compound comprising albumin-paclitaxel nanoparticles (NPs-PTX) with a drug loading efficiency of 21% was constructed via manipulation of alkali induced conformation changes and hydrophilic-hydrophobicity transition. The toxicity of two PTX formulations (Taxol and NPs-PTX) in human umbilical vein endothelial cells (HUVECs), RAW264.7, K562, and HepG2 cells, and rats were determined. The half maximal inhibitory concentration (IC |
| Databáze: | OpenAIRE |
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