Circadian Rhythm and Sleep Disruption: Causes, Metabolic Consequences, and Countermeasures
| Autor: | Gregory D. M. Potter, Peter J. Grant, Debra J. Skene, Laura J. Hardie, Josephine Arendt, Janet E Cade |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Endocrinology Diabetes and Metabolism Population Reviews Biology 03 medical and health sciences Health problems 0302 clinical medicine Endocrinology Sleep Disorders Circadian Rhythm Internal medicine medicine Humans Circadian rhythm education Chronobiology Phenomena education.field_of_study Artificial light Sleep in non-human animals 3. Good health Sleep deprivation 030104 developmental biology Increased risk 13. Climate action Sleep Deprivation medicine.symptom Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Endocrine Reviews |
| ISSN: | 1945-7189 0163-769X |
| DOI: | 10.1210/er.2016-1083 |
| Popis: | Circadian (∼24-hour) timing systems pervade all kingdoms of life and temporally optimize behavior and physiology in humans. Relatively recent changes to our environments, such as the introduction of artificial lighting, can disorganize the circadian system, from the level of the molecular clocks that regulate the timing of cellular activities to the level of synchronization between our daily cycles of behavior and the solar day. Sleep/wake cycles are intertwined with the circadian system, and global trends indicate that these, too, are increasingly subject to disruption. A large proportion of the world's population is at increased risk of environmentally driven circadian rhythm and sleep disruption, and a minority of individuals are also genetically predisposed to circadian misalignment and sleep disorders. The consequences of disruption to the circadian system and sleep are profound and include myriad metabolic ramifications, some of which may be compounded by adverse effects on dietary choices. If not addressed, the deleterious effects of such disruption will continue to cause widespread health problems; therefore, implementation of the numerous behavioral and pharmaceutical interventions that can help restore circadian system alignment and enhance sleep will be important. |
| Databáze: | OpenAIRE |
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