Influence of the Duration of Type 2 Diabetes on Early Functional and Morphological Markers of Atherosclerosis Compared to the Impact of Coexisting Classic Cardiovascular Risk Factors
| Autor: | Harald Klein, D. Lieps, Helmut Schatz, M. Pfohl, M. F. Meyer |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Brachial Artery Endocrinology Diabetes and Metabolism Hypercholesterolemia Type 2 diabetes Endocrinology Risk Factors Internal medicine medicine.artery Diabetes mellitus Internal Medicine medicine Humans Brachial artery Endothelial dysfunction Reactive hyperemia Aged Ultrasonography Aged 80 and over Glycated Hemoglobin Hypertriglyceridemia business.industry Smoking General Medicine Middle Aged Atherosclerosis medicine.disease Diabetes Mellitus Type 2 Intima-media thickness Case-Control Studies Hypertension cardiovascular system Cardiology Female Metabolic syndrome business Biomarkers |
| Zdroj: | Experimental and Clinical Endocrinology & Diabetes. 116:298-304 |
| ISSN: | 1439-3646 0947-7349 |
| DOI: | 10.1055/s-2008-1042404 |
| Popis: | AIM The increased incidence of atherosclerotic macrovascular disease in type 2 diabetic patients is associated both with diabetes specific factors and coexisting classic cardiovascular risk factors as components of the metabolic syndrome. The aim of this study was to investigate the association between the duration of diabetes and early functional and morphological markers of atherosclerosis compared to the impact of coexisting cardiovascular risk factors such as hypertension, dyslipoproteinemia and cigarette smoking. METHODS 63 type 2 diabetic patients and 25 non-diabetic control subjects were investigated. Lumen diameter of the brachial artery was measured by high-resolution ultrasound at rest and after 5-min suprasystolic arterial compression. Endothelium-independent dilatation of the brachial artery was measured 4 min after sublingual administration of 400 mug of glycerol trinitrate (GTN). Percentage change of arterial lumen diameter during reactive hyperemia (FMD%) and after GTN administration (GTN%) relative to the baseline measurements were calculated. The intima-media thickness (IMT) of the common carotid artery was measured bilaterally and averages were calculated. RESULTS FMD% (3.8+/-0.8% vs. 6.9+/-0.9%; p |
| Databáze: | OpenAIRE |
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