Independent expression of cyclic AMP dependent protein kinases related to cyclic nucleotide systems, during triiodothyronine induced cardiac hypertrophy
| Autor: | D. Bogdanovsky-Sequeval, Georges Schapira, L. Bachner, B. Kneip, Michel Raymondjean |
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| Rok vydání: | 1980 |
| Předmět: |
Male
medicine.medical_specialty Cardiomegaly Biology Isozyme General Biochemistry Genetics and Molecular Biology Muscle hypertrophy Cyclic nucleotide chemistry.chemical_compound Cytosol Internal medicine Cyclic AMP medicine Animals General Pharmacology Toxicology and Pharmaceutics Protein kinase A Cyclic GMP Triiodothyronine Kinase Myocardium Organ Size General Medicine Rats Isoenzymes Endocrinology chemistry Specific activity Protein Kinases Function (biology) |
| Zdroj: | Life Sciences. 27:387-394 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(80)90186-1 |
| Popis: | The amount of type I and type II cyclic AMP dependent protein kinase present in rat heart was determined at differents times during triiodothyronine (T3) induced cardiac hypertrophy. A difference between the two isozymes was observed, with two maximum kinase levels for isozyme I during the first 24 hours of hypertrophic treatment. At the same time the level of cyclic AMP was significantly increased and, to a lesser extent, that of cyclic GMP. The variation of the activity ratio (-cyclic AMP/+ cyclic AMP) during T3 treatment indicates a modification of the state of activation of the cyclic AMP dependent protein kinases. The specific activity of isozyme II protein kinase did not change significantly at the beginning of hypertrophy, it increased only between day 3 and 7 as did isozyme I. These observations may indicate a different regulatory function of the two isozymes in response to T3 induced cardiac hypertrophy. |
| Databáze: | OpenAIRE |
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